M1434
2-甲基硫腺苷 5′-单磷酸 三乙铵盐 水合物
≥98% (HPLC), solid
别名:
2-MeSAMP, 2-甲硫基-AMP 三乙铵盐 水合物
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关于此项目
经验公式（希尔记法）:
C11H16N5O7PS · xC6H15N × yH2O
化学文摘社编号:
分子量:
393.31 (anhydrous free acid basis)
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
产品名称
2-甲基硫腺苷 5′-单磷酸 三乙铵盐 水合物, solid, ≥98% (HPLC)
SMILES string
O.CCN(CC)CC.CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1
InChI
1S/C11H16N5O7PS.C6H15N.H2O/c1-25-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(23-10)2-22-24(19,20)21;1-4-7(5-2)6-3;/h3-4,6-7,10,17-18H,2H2,1H3,(H2,12,14,15)(H2,19,20,21);4-6H2,1-3H3;1H2/t4-,6-,7-,10-;;/m1../s1
InChI key
YQMUWWZKFZERBT-IDIVVRGQSA-N
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: 20 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
相关类别
Application
2-甲硫基腺嘌呤5′单磷酸三乙铵盐水合物已用于:
- 作为P2Y12 抑制剂用于研究其对高密度脂蛋白（HDL）内噬的刺激作用。
- 作为P2Y12 抑制剂用于研究其对全人血中血小板募集的作用。
Biochem/physiol Actions
2-甲硫基腺嘌呤5′-单磷酸三乙铵盐水合物(2-MeSAMP) 是一种腺苷基P2Y12拮抗剂 和ADP依赖性血小板凝集抑制剂。(1)它可能通过P2Y12/G(i)-依赖性机制抑制血小板活化。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Effects of P2Y1 receptor antagonism on the reactivity of platelets from patients with stable coronary artery disease using aspirin and clopidogrel.
Labarthe B, Babin J, Bryckaert M, et al.
British Journal of Pharmacology, 166(1), 221-231 (2011)
J P Brammer et al.
British journal of pharmacology, 82(1), 61-72 (1984-05-01)
Palmitaldehyde acetal phosphatidic acid ( PGAP ) caused dose-dependent aggregation of human platelets resuspended in modified Tyrode medium, with a threshold concentration of 0.5-1 microM and an EC50 of 4 microM. Concentrations of PGAP which elicited biphasic irreversible aggregation concomitantly
Ben R Watson et al.
Metallomics : integrated biometal science, 8(1), 91-100 (2015-10-06)
Following platelet adhesion and primary activation at sites of vascular injury, secondary platelet activation is induced by soluble platelet agonists, such as ADP, ATP, thrombin and thromboxane. Zinc ions are also released from platelets and damaged cells and have been
Li Dong et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 130, 110537-110537 (2020-07-28)
Rhizoma Bletillae, the tubes of Bletilla striata, has been traditionally used in China as a hemostatic agent. In preliminary studies, the major active fraction responsible for its hemostatic effect have been confirmed to be Rhizoma Bletillae polysaccharide (RBp), but the
Nagaraj Manickam et al.
British journal of haematology, 142(3), 457-465 (2008-06-10)
Sulfhydryl groups of platelet surface proteins are important in platelet aggregation. While p-chloromercuribenzene sulphonate (pCMBS) has been used in most studies on platelet surface thiols, the specific thiol-proteins that pCMBS reacts with to inhibit aggregation have not been well defined.
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