M149
甲硫替平 甲磺酸盐
≥98% (HPLC), solid
别名:
1-[10，11-二氢-8-（甲硫基）二苯并[b，f]硫平-10-基]-4-甲基哌嗪 甲磺酸盐, 甲替平 甲磺酸盐
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关于此项目
线性分子式:
C20H24N2S2 · CH3SO3H
化学文摘社编号:
分子量:
452.65
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
甲硫替平 甲磺酸盐, ≥98% (HPLC), solid
InChI key
CZMDZGZYKOGLJY-UHFFFAOYSA-N
SMILES string
CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1
InChI
1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: 13 mg/mL
Quality Level
Gene Information
human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR6(3362), HTR7(3363)
Application
甲硫替平甲磺酸盐已用于探索循环细胞与生态位之间的关系。它也已用于5-羟色胺（5-HT）和拮抗剂体内生物测定以及体内拮抗剂和脂多糖刺激。
Biochem/physiol Actions
甲硫替平甲磺酸盐是一种5-HT1、5-HT6、5-HT75-羟色胺受体拮抗剂，可阻断5-羟色胺自身受体。
General description
甲硫替平属于一类新的二苯并噻吩。甲硫替平具有精神抑制活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Naunyn-Schmiedeberg'S Archives of Pharmacology, 274(2), 192-197 (1972)
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Benton J L, et al.
BMC Neuroscience, 12(1), 53-53 (2011)
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