M1508
羟甲香豆素 钠盐
fluorogenic, ≥98% (HPLC), crystalline
别名:
7-羟基-4-甲基香豆素, β-甲基伞形酮
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关于此项目
线性分子式:
C10H7O3Na
化学文摘社编号:
分子量:
198.15
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
227-790-1
MDL number:
产品名称
羟甲香豆素 钠盐, ≥98% (HPLC), crystalline
InChI key
JGMQHDNPUCPRQE-UHFFFAOYSA-M
InChI
1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
SMILES string
[Na+].CC1=CC(=O)Oc2cc([O-])ccc12
assay
≥98% (HPLC)
form
crystalline
color
yellow
solubility
water: 50 mg/mL
Quality Level
Application
4-甲基伞形酮钠盐已用于：
- 作为底物，分析其在人体肝脏中葡萄糖醛酸化的酶动力学
- 作为定量酶底物作用释放的游离 4-甲基伞形酮的标准品
- 抑制透明质酸（HA）生成的细胞内存活试验及其对卵巢癌症化疗耐药性的影响
Biochem/physiol Actions
4-甲基伞形酮（4-MU）作为透明质酸（HA）合成阻断剂。它具有抗炎、抗纤维生成和抗肿瘤的特性。4-甲基伞形酮用于治疗胆汁痉挛，也可能对非酒精性脂肪性肝炎（NASH）、炎症、肝细胞损伤和纤维化反应有益。已知 4-甲基伞形酮被人类肝脏的大多数尿苷 5ฺ-二磷酸葡萄糖醛酸基转移酶（UGT）异构体葡萄糖醛酸化。这使其成为检测整个肝脏 UGT 活性的有效探针底物。
General description
4-甲基伞形酮（4-MU）是一种香豆素衍生物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Valérie Jaulneau et al.
Journal of biomedicine & biotechnology, 2010, 525291-525291 (2010-05-07)
The industrial use of elicitors as alternative tools for disease control needs the identification of abundant sources of them. We report on an elicitor obtained from the green algae Ulva spp. A fraction containing most exclusively the sulfated polysaccharide known
Gale E Smith et al.
Virology, 509, 90-97 (2017-06-19)
Avian influenza A (H5N1) viruses represent a growing threat for an influenza pandemic. The presence of widespread avian influenza virus infections further emphasizes the need for vaccine strategies for control of pre-pandemic H5N1 and other avian influenza subtypes. Influenza neuraminidase
Ai-Sheng Xiong et al.
PloS one, 6(11), e26773-e26773 (2011-11-19)
A β-glucuronidase variant, GUS-TR3337, that was obtained by directed evolution exhibited higher thermostability than the wild-type enzyme, GUS-WT. In this study, the utility of GUS-TR337 as an improved reporter was evaluated. The corresponding gus-tr3337 and gus-wt genes were independently cloned
Matías A Pibuel et al.
Glycobiology, 31(1), 29-43 (2020-05-31)
Glioblastoma (GBM), the most frequent primary tumor of the central nervous system, has a median survival of 14.6 months. 4-Methylumbelliferone (4MU) is a coumarin derivative widely used as a hyaluronan synthesis inhibitor with proven antitumor activity and without toxic effects reported.
Molly Stapleton et al.
Molecular genetics and metabolism reports, 22, 100563-100563 (2020-01-21)
Mucopolysaccharidoses (MPS) are a family of lysosomal storage disorders which can lead to degenerative and irreversible skeletal, cardiovascular, pulmonary, and neurological damage. Current treatments, including hematopoietic stem cell transplantation and enzyme replacement therapy, have been found most effective if administered
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