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M1568

甘露糖三氟磺酸酯

Name: 甘露糖三氟磺酸酯
Brand: SIGMA

For PET imaging, ≥98% (TLC)

别名:

β-D-甘露吡喃糖1,3,4,6-四- O -乙酸盐 2- O -三氟甲磺酸酯, 1,3,4,6-四-O-乙酰基-2-O-三氟甲磺酰-β-D-吡喃甘露糖, TATM, 甘露糖三氟甲磺酸酯

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关于此项目

经验公式（希尔记法）:

C₁₅H₁₉F₃O₁₂S

化学文摘社编号:

92051-23-5

分子量:

480.36

UNSPSC Code:

41116107

NACRES:

NA.12

PubChem Substance ID:

24896669

MDL number:

MFCD00012353

Beilstein/REAXYS Number:

4341413

Assay:

≥98% (TLC)

Form:

powder

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Quality Level

200

assay

≥98% (TLC)

form

powder

technique(s)

PET imaging: suitable

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@@H](OS(=O)(=O)C(F)(F)F)[C@@H](OC(C)=O)[C@@H]1OC(C)=O

InChI

1S/C15H19F3O12S/c1-6(19)25-5-10-11(26-7(2)20)12(27-8(3)21)13(14(29-10)28-9(4)22)30-31(23,24)15(16,17)18/h10-14H,5H2,1-4H3/t10-,11-,12+,13+,14-/m1/s1

InChI key

OIBDVHSTOUGZTJ-PEBLQZBPSA-N

General description

Mannose triflate is a glucose analogue.

Application

Mannose triflate is a well-known precursor for ¹⁸F-FDG synthesis for PET applications. The binding of ¹⁸F to the mannose triflate has been carried out via SN₂nucleophilic substitution reaction. It is used in computational tomography, an imaging technique in early detection of cancer.

Other Notes

This formulation of mannose triflate has reduced trace impurities that are known to cause lower synthetic yields.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Characterization of a novel murine model for spontaneous hemorrhagic stroke using in vivo PET and MR multiparametric imaging.

Salvador Castaneda Vega et al.

NeuroImage, 155, 245-256 (2017-05-06)

The clinical use of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) has proven to be a strong diagnostic tool in the field of neurology. The reliability of these methods to confirm clinical diagnoses has guided preclinical research to

Simplified programming and control of automated radiosynthesizers through unit operations.

Shane B Claggett et al.

EJNMMI research, 3(1), 53-53 (2013-07-17)

Many automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed with the engineer rather than the radiochemist in mind, requiring lengthy programs to

Padgett, H., et al.

Applied Radiation and Isotopes, 40, 433-433 (1989)

Gold nanoparticle probes: design and in vitro applications in cancer cell culture.

Gulcan Unak et al.

Colloids and surfaces. B, Biointerfaces, 90, 217-226 (2011-11-11)

A new architecture has been designed by the conjugation of [(18)F]2-fluoro-2-deoxy-D-glucose ((18)F-FDG), gold nanoparticles (AuNPs), and anti-metadherin (Anti-MTDH) antibody which is specific to the metadherin (MTDH) over-expressed on the surface of breast cancer cells. Mannose triflate molecule is used as

Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution.

K Hamacher et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 27(2), 235-238 (1986-02-01)

An aminopolyether mediated synthesis of fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) has been developed. The nucleophilic fluorination with accelerator-produced [18F]fluoride works at the no-carrier-added level and gives epimerically pure 2-18FDG with an uncorrected radiochemical yield of a maximum 50% in a synthesis

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全球贸易项目编号

货号	GTIN
M1568-20MG	04061833290149
M1568-40MG	04061833290163
M1568-100MG	04061833285411
M1568-10X25MG	04061833247488
M1568-25MG	04061833290156

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