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M157

MEN-10,376

Name: MEN-10,376
Brand: SIGMA

≥95% (HPLC), solid

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关于此项目

经验公式（希尔记法）:

C₅₇H₆₈N₁₂O₁₀

化学文摘社编号:

135306-85-3

分子量:

1081.22

NACRES:

NA.32

PubChem Substance ID:

24896670

UNSPSC Code:

51111800

MDL number:

MFCD00144736

Form:

solid

Assay:

≥95% (HPLC)

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属性

Quality Level

200

assay

≥95% (HPLC)

form

solid

color

white

storage temp.

−20°C

SMILES string

CC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(N)CC(O)=O)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CCCCN)C(N)=O

InChI

1S/C57H68N12O10/c1-31(2)50(69-56(78)48(26-35-30-63-43-16-8-5-13-39(35)43)67-53(75)45(23-32-18-20-36(70)21-19-32)65-52(74)40(59)27-49(71)72)57(79)68-47(25-34-29-62-42-15-7-4-12-38(34)42)55(77)66-46(24-33-28-61-41-14-6-3-11-37(33)41)54(76)64-44(51(60)73)17-9-10-22-58/h3-8,11-16,18-21,28-31,40,44-48,50,61-63,70H,9-10,17,22-27,58-59H2,1-2H3,(H2,60,73)(H,64,76)(H,65,74)(H,66,77)(H,67,75)(H,68,79)(H,69,78)(H,71,72)

InChI key

QQHOFZNACVKNHK-UHFFFAOYSA-N

Gene Information

human ... TACR2(6865)

说明

Biochem/physiol Actions

Potent and selective NK-2 tachykinin receptor antagonist.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Effects of substance P on identified neurons of the rat dorsal motor nucleus of the vagus.

M W Lewis et al.

American journal of physiology. Gastrointestinal and liver physiology, 281(1), G164-G172 (2001-06-16)

Previous evidence suggests that substance P (SP) activates subpopulations of neurons within the dorsal motor nucleus of the vagus (DMV). In this study we aimed at identifying these subpopulations in relation to their gastrointestinal projection organs or vagal branches and

Proteinase-activated receptor-2 activation evokes oesophageal longitudinal smooth muscle contraction via a capsaicin-sensitive and neurokinin-2 receptor-dependent pathway.

H Liu et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 22(2), 210-216 (2009-09-11)

Intraluminal acid evokes sustained oesophageal longitudinal smooth muscle (LSM) contraction and oesophageal shortening, which may play a role in oesophageal pain and the aetiology of hiatus hernia. In the opossum model, this reflex has been shown to involve mast cell

Abuse liability of the dietary supplement dimethylamylamine.

Sean B Dolan et al.

Drug and alcohol dependence, 146, 97-102 (2014-12-08)

Dimethylamylamine (DMAA) is a component of many dietary supplements and has recently been associated with numerous adverse effects, prompting the US military and World Anti-Doping Agency to ban its use as a supplement. The current study aimed to elucidate the

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全球贸易项目编号

货号	GTIN
M157-500UG	04061832677200