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Merck
CN

M1629

17-醋酸甲羟孕酮

synthetic (organic), ≥97% (HPLC), synthetic progestogen, powder

别名:

17α-乙酰氧基-6α-甲基孕酮, 17α-羟基-6α-甲基-4-孕烯-3,20-二酮 17-乙酸酯, 6α-甲基-17α-羟基孕酮乙酸酯, 6α-甲基-17α-羟孕酮醋酸酯

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关于此项目

经验公式（希尔记法）:
C24H34O4
化学文摘社编号:
71-58-9
分子量:
386.52
NACRES:
NA.77
PubChem Substance ID:
24896674
UNSPSC Code:
12352200
EC Number:
200-757-9
MDL number:
MFCD00010483
Beilstein/REAXYS Number:
2066112

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产品名称

17-醋酸甲羟孕酮, ≥97% (HPLC)

InChI

1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1

SMILES string

[H][C@@]12C[C@H](C)C3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(OC(C)=O)C(C)=O

InChI key

PSGAAPLEWMOORI-PEINSRQWSA-N

biological source

synthetic (organic)

sterility

non-sterile

assay

≥97% (HPLC)

form

powder

mp

206-207 °C (lit.)

solubility

chloroform: 350 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

Quality Level

100

Gene Information

human ... AR(367), ESR1(2099), ESRRA(2101), NR3C1(2908), NR3C2(4306), PGR(5241)
rat ... Ar(24208)

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相关类别

Biochem/physiol Actions

醋酸甲羟孕酮（MPA）是一种合成的孕激素，在激素替代疗法和子宫内膜异位症中用作避孕药。 与非乙酰化形式相比，它是更有效的孕激素。

Features and Benefits

该化合物是受体分类及信号转导手册上核受体（类固醇）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351,H413

Hazard Classifications

Aquatic Chronic 4 - Carc. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF6614V
MKCX1330
WXBD8263V
MKCK5867
MKCK3868

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Milan Milenkovic et al.
Journal of assisted reproduction and genetics, 28(1), 7-14 (2010-09-16)
To evaluate a slow freezing method for whole ovary cryopreservation by evaluating effects of added cryoprotectant. Sheep ovaries were isolated during surgery, flushed with either Ringer-Acetate or dimethylsulphoxide and cryopreserved by slow freezing. After rapid thawing, viability was assessed by
Liangzhu Li et al.
PloS one, 7(8), e43211-e43211 (2012-08-21)
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Ozlem Guzeloglu Kayisli et al.
PloS one, 10(10), e0137855-e0137855 (2015-10-06)
Use of long-acting progestin only contraceptives (LAPCs) offers a discrete and highly effective family planning method. Abnormal uterine bleeding (AUB) is the major side effect of, and cause for, discontinuation of LAPCs. The endometria of LAPC-treated women display abnormally enlarged
Bernhard Payer et al.
Molecular cell, 52(6), 805-818 (2013-11-26)
Transitions between pluripotent and differentiated states are marked by dramatic epigenetic changes. Cellular differentiation is tightly linked to X chromosome inactivation (XCI), whereas reprogramming to induced pluripotent stem cells (iPSCs) is associated with X chromosome reactivation (XCR). XCR reverses the
S Saoncella et al.
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