M1777
N-Methyl-1-deoxynojirimycin
≥98%
别名:
1,5-Dideoxy-1,5-imino-1-methyl-D-sorbitol
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关于此项目
经验公式（希尔记法）:
C7H15NO4
化学文摘社编号:
分子量:
177.20
Beilstein:
1524564
MDL编号:
UNSPSC代码:
51102829
PubChem化学物质编号:
NACRES:
NA.32
生物来源
synthetic (organic)
方案
≥98%
表单
powder
溶解性
methanol: 10 mg/mL, clear, colorless
抗生素抗菌谱
viruses
作用机制
enzyme | inhibits
储存温度
−20°C
SMILES字符串
CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI
1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
InChI key
AAKDPDFZMNYDLR-XZBKPIIZSA-N
基因信息
mouse ... Gaa(14387), Glb1(12091), Treh(58866)
rat ... Man2a1(25478), Si(497756)
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一般描述
Chemical structure: glucosamine
生化/生理作用
Interferes with metabolism of N-linked glycoproteins by inhibition of glucosidase.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Diego A Caraballo et al.
G3 (Bethesda, Md.), 10(2), 755-768 (2019-12-05)
UDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding. It is known that vertebrates and Caenorhabditis genomes harbor two uggt gene copies that exhibit differences
R Carroll et al.
The Biochemical journal, 285 ( Pt 3), 693-696 (1992-08-01)
Incubation of cycloheximide-treated cardiac myocytes results in a time-dependent increase in cellular and heparin-releasable lipoprotein lipase (LPL) activities. N-Methyldeoxynojirimycin (1 mM) and castanospermine (100 micrograms/ml), inhibitors of glucosidases in the endoplasmic reticulum (ER), prevented the increase in cellular LPL activity.
E D Faber et al.
Pharmaceutical research, 11(1), 144-150 (1994-01-01)
The hepatic disposition of two glycosidase inhibitors was studied in the isolated perfused rat liver and after subcellular fractionation. The mannosidase inhibitor 1-deoxymannojirimycin (dMM) and the glucosidase inhibitor N-methyl-1-deoxynojirimycin (MedNM) exhibited minimal binding to albumin and reached liver concentrations that
M Arai et al.
British journal of pharmacology, 133(5), 635-642 (2001-06-29)
Preischaemic treatment with N-methyl-1-deoxynojirimycin (MOR-14), an alpha-1,6-glucosidase inhibitor, attenuates glycogenolysis and lactate accumulation during ischaemia and markedly reduces infarct size in rabbit hearts. In the present study, we have investigated whether protein kinase C (PKC), a principal mediator of ischaemic
G C Trudel et al.
Biochemical and biophysical research communications, 184(1), 125-130 (1992-04-15)
The glycoprotein processing inhibitors bromoconduritol and N-methyl-1-deoxynojirimycin inhibit myoblast fusion and differentiation, suggesting the critical involvement of one or more glycoproteins in the control of skeletal myogenesis. In the present study we have examined the effect of inhibitors of glycoprotein
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