M1777
N-Methyl-1-deoxynojirimycin
≥98%
别名:
1,5-Dideoxy-1,5-imino-1-methyl-D-sorbitol
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关于此项目
经验公式（希尔记法）:
C7H15NO4
化学文摘社编号:
分子量:
177.20
UNSPSC Code:
51102829
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1524564
InChI
1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
SMILES string
CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI key
AAKDPDFZMNYDLR-XZBKPIIZSA-N
biological source
synthetic (organic)
assay
≥98%
form
powder
solubility
methanol: 10 mg/mL, clear, colorless
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
storage temp.
−20°C
Quality Level
Gene Information
mouse ... Gaa(14387), Glb1(12091), Treh(58866)
rat ... Man2a1(25478), Si(497756)
General description
Chemical structure: glucosamine
Biochem/physiol Actions
Interferes with metabolism of N-linked glycoproteins by inhibition of glucosidase.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Diego A Caraballo et al.
G3 (Bethesda, Md.), 10(2), 755-768 (2019-12-05)
UDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding. It is known that vertebrates and Caenorhabditis genomes harbor two uggt gene copies that exhibit differences
G C Trudel et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 66(10), 1119-1125 (1988-10-01)
It has recently been reported that the glucosidase I inhibitor, N-methyl-1-deoxynojirimycin (MDJN), inhibits myoblast fusion whereas the mannosidase inhibitor, 1-deoxymannojirimycin (ManDJN), has no effect on fusion. We now report that bromoconduritol, which is an active-site-directed covalent inhibitor of glucosidase II
D J Wu et al.
Japanese circulation journal, 65(7), 673-677 (2001-07-12)
N-methyl-1-deoxynojirimycin (NMDN), an a-glucosidase inhibitor, reduces myocardial infarct size by reducing the glycogenolytic rate through inhibition of the alpha-1,6-glucosidase of glycogen-debranching enzyme in the heart, in addition to possessing an antihyperglycemic action by blocking alpha-1,4-glucosidase in the intestine. Ischemic preconditioning
K Matter et al.
The Journal of biological chemistry, 264(22), 13131-13139 (1989-08-05)
Intestinal brush border enzyme glycoproteins are transported to the microvillar membrane at different rates in the differentiated intestinal cell line Caco-2. This asynchronism is due to at least two rate-limiting events, a pre- and an intra-Golgi step (Stieger B., Matter
J C Ridruejo et al.
Biochimica et biophysica acta, 993(2-3), 179-185 (1989-12-08)
Castanospermine, 1-deoxynojirimycin, and N-methyl-1-deoxynojirimycin, three well-characterized inhibitors of the glucosidases involved in the processing of N-linked oligosaccharides, did not affect the biosynthesis or the secretion of exoglucanases (EC 3.2.1.58) from Saccharomyces cerevisiae and Candida albicans but inhibited the activity itself.
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