M1809
MRS 1523
>98% (HPLC)
别名:
3-Propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate
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关于此项目
经验公式（希尔记法）:
C23H29NO3S
化学文摘社编号:
分子量:
399.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
MRS 1523, >98% (HPLC)
InChI
1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3
SMILES string
CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(CC)nc1-c2ccccc2
InChI key
UUSHFEVEROROSP-UHFFFAOYSA-N
assay
>98% (HPLC)
form
oil
color
colorless to light brown
solubility
DMSO: >10 mg/mL
H2O: insoluble
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
Application
MRS 1523 has been used as an inhibitor of adenosine receptors in SW1990 and BxPC3 pancreatic cancer cells, LX2 human hepatic stellate cells and human coronary smooth muscle cells.
Biochem/physiol Actions
MRS 1523 is a selective adenosine A3 receptor antagonist in the rat.
Features and Benefits
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
Sold under license from the National Institutes of Health
wgk
WGK 3
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
The A3 adenosine receptor agonist, namodenoson, ameliorates non-alcoholic steatohepatitis in mice
Fishman P, et al.
International Journal of Molecular Medicine, 44(6), 2256-2264 (2019)
C H Mitchell et al.
The American journal of physiology, 276(3 Pt 1), C659-C666 (1999-03-10)
Adenosine stimulates Cl- channels of the nonpigmented (NPE) cells of the ciliary epithelium. We sought to identify the specific adenosine receptors mediating this action. Cl- channel activity in immortalized human (HCE) NPE cells was determined by monitoring cell volume in
Shira Cohen et al.
Journal of immunology research, 2018, 2310970-2310970 (2018-06-05)
Interleukin-17 and interleukin-23 play major roles in the inflammatory process in psoriasis. The Gi protein-associated A3 adenosine receptor (A3AR) is known to be overexpressed in inflammatory cells and in peripheral blood mononuclear cells (PBMCs) of patients with autoimmune inflammatory conditions.
A H Li et al.
Journal of medicinal chemistry, 41(17), 3186-3201 (1998-08-14)
The structure-activity relationships of 6-phenyl-1,4-dihydropyridine derivatives as selective antagonists at human A3 adenosine receptors have been explored (Jiang et al. J. Med. Chem. 1997, 39, 4667-4675). In the present study, related pyridine derivatives have been synthesized and tested for affinity
Elena Lucarini et al.
Pain, 161(9), 2179-2190 (2020-05-08)
Pharmacological tools for chronic visceral pain management are still limited and inadequate. A3 adenosine receptor (A3AR) agonists are effective in different models of persistent pain. Recently, their activity has been related to the block of N-type voltage-gated Ca2+ channels (Cav2.2)
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