M216
MDL 105,519
≥98% (HPLC), NMDA receptor antagonist, solid
别名:
(E)-4,6-Dichloro-3-(2-phenyl-2-carboxyethenyl)indole-2-carboxylic acid
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关于此项目
经验公式（希尔记法）:
C18H11Cl2NO4
化学文摘社编号:
分子量:
376.19
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
MDL 105,519, ≥98% (HPLC), solid
SMILES string
OC(=O)C(=C/c1c([nH]c2cc(Cl)cc(Cl)c12)C(O)=O)\c3ccccc3
InChI
1S/C18H11Cl2NO4/c19-10-6-13(20)15-12(16(18(24)25)21-14(15)7-10)8-11(17(22)23)9-4-2-1-3-5-9/h1-8,21H,(H,22,23)(H,24,25)/b11-8-
InChI key
LPWVUDLZUVBQGP-FLIBITNWSA-N
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: >20 mg/mL
Quality Level
Gene Information
human ... GRIN1(2902)
rat ... Grin1(24408)
Biochem/physiol Actions
MDL 105,519 is a high affinity N-methyl-D-aspartate (NMDA) glutamate receptor antagonist at the glycine site. It inhibits NMDA-dependent responses.
Legal Information
Sold under exclusive license from Hoechst Marion Roussel, Inc.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
B M Baron et al.
European journal of pharmacology, 323(2-3), 181-192 (1997-04-04)
MDL 105,519, (E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1 H-indole-2-carboxylic acid, is a potent and selective inhibitor of [3H]glycine binding to the NMDA receptor. MDL 105,519 inhibits NMDA (N-methyl-D-aspartate)-dependent responses including elevations of [3H]N-[1,(2-thienyl)cyclohexyl]-piperidine ([3H]TCP) binding in brain membranes, cyclic GMP accumulation in brain slices, and
Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist.
Baron BM
European Journal of Pharmacology, 323(2-3), 181-192 (1997)
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