M221
Monoclonal Anti-Nicotinic Acetylcholine Receptor (α3 Subunit) antibody produced in rat
~5 mg/mL, clone mAb 313, affinity isolated antibody, buffered aqueous solution
biological source
rat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
mAb 313, monoclonal
form
buffered aqueous solution
species reactivity
chicken
concentration
~5 mg/mL
technique(s)
immunohistochemistry (frozen sections): 1:4,000
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
chicken ... CHRNA3(386578)
Immunogen
recombinant large cytoplasmic domain of the α3 subunit (amino acids 315-441) of the nicotinic acetylcholine receptor from chick.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Binds to native and denatured detergent-solubilized α3 subunit of AchR. Does not bind α1, α4, α5, α7, α8 and β2.
Physical form
Solution in 20 mM Na3PO4, pH 7.2, containing 150 mM NaCl and 0.05% sodium azide.
Legal Information
Sold with permission of the Salk Institute
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
P J Whiting et al.
Brain research. Molecular brain research, 10(1), 61-70 (1991-04-01)
Neuronal nicotinic acetylcholine receptors (AChRs) are composed of two types of subunits: ACh-binding (termed alpha 2, alpha 3, alpha 4 ...) and structural (termed beta 2, beta 3, beta 4 ...). AChR subtypes composed of combinations of subunits of these
Lindstrom
Neurotransmissions, 12, 2-2 (1996)
Margarita Villar et al.
Biomolecules, 10(4) (2020-04-09)
Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating
W G Conroy et al.
Neuron, 9(4), 679-691 (1992-10-01)
The acetylcholine receptor (AChR) alpha 5 gene has been classified as a member of the AChR gene family based on sequence homology. Expression studies, however, have yet to identify a function for the alpha 5 gene product or even to
Benjaporn Buranrat et al.
Oncology reports, 34(5), 2790-2796 (2015-09-10)
Ferritin is a major iron storage protein and essential for iron homeostasis. It has a wide range of functions in the body including iron delivery, immunosuppression, angiogenesis, and cell proliferation. Ferritin is overexpressed in many cancer cells, but its precise
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