M2378
黏液蛋白 来源于猪胃
Type II
别名:
MUC
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关于此项目
Form:
powder
Biological source:
Porcine stomach
biological source
Porcine stomach
Quality Level
type
Type II
form
powder
composition
bound sialic acid, ≤1.2%
technique(s)
cell culture | mammalian: suitable
solubility
1 M NaOH: soluble 20 mg/mL
UniProt accession no.
storage temp.
2-8°C
Gene Information
pig ... MUC2(100127145)
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General description
粘蛋白主要由碳水化合物单元组成，对结构结构和构象至关重要。粘蛋白的单体为640 kDa，蛋白质仅占分子量的20％。其中的碳水化合物成分附着在苏氨酸和丝氨酸侧链上。粘蛋白分为分泌型和跨膜粘蛋白。
黏液蛋白或黏液糖蛋白是哺乳动物黏液的主要大分子成分。它还被应用于评价细胞离心浓缩痰涂片检测抗酸杆菌的研究。
Application
来自猪胃的粘蛋白以用于：
- 绘制定量小鼠粘膜炎症过程产生的粘蛋白2的标准曲线
- 用作人体外消化模型中的消化液溶液组分
- 用作模拟唾液的组分
猪胃黏液素已应用于 铜绿假单胞菌半乳糖特异性凝集素PA-IL结合位点的研究。
Biochem/physiol Actions
粘蛋白在药物递送应用中具有广泛的药理学应用。粘蛋白在炎症过程中起着保护作用。粘蛋白合成失调有可能引起肿瘤发生和慢性炎症。
黏液形成所有上皮表面的保护层。黏液的主要结构成分是形成凝胶的黏液素。覆盖肠上皮的黏液层以MUC2粘蛋白为中心分子。MUC2是由杯状细胞产生。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
此项目有
Structural investigation of porcine stomach mucin by X-ray fiber diffraction and homology modeling
Veluraja K, et al.
Biochemical and biophysical research communications, 406(4), 570-573 (2011)
Mucins in cancer: function, prognosis and therapy
Kufe DW
Nature Reviews. Cancer, 9(12), 874-874 (2009)
Enhancement of the solubility, stability and bioaccessibility of quercetin using protein-based excipient emulsions
Chen X, et al.
Food Research International, 114, 30-37 (2018)
Melinda A Engevik et al.
ACS infectious diseases, 7(5), 1126-1142 (2020-11-13)
It is widely accepted that the pathogen Clostridioides difficile exploits an intestinal environment with an altered microbiota, but the details of these microbe-microbe interactions are unclear. Adherence and colonization of mucus has been demonstrated for several enteric pathogens and it
An optimized purification process for porcine gastric mucin with preservation of its native functional properties
Schomig VJ, et al.
Royal Society of Chemistry Advances, 6(50), 44932-44943 (2016)
商品
Understand sialic acid structure, function, signaling, and modifications. Easily find products for sialic acid research.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M2378-500G | 04061834041917 |
| M2378-100G | 04061835546152 |
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