一般描述
产生小鼠IgM的MOPC-104E肿瘤系是矿物油诱导的浆细胞瘤，起源于BALB/c小鼠并腹膜内携带。小鼠具有五种类型的免疫球蛋白 - IgM，IgG，IgA，IgD和IgE。IgM以单体形式存在于B淋巴细胞表面。
应用
来自鼠骨髓瘤的IgMλ在GATA-1-null和GATA-1阳性G1E细胞的ChIP分析中用作对照抗体。
来自鼠骨髓瘤的IgMλ已被用作染色质免疫沉淀分析的对照。它也被用于免疫组织化学。
生化/生理作用
IgM抗体在血清中以五聚体的形式存在，为响应抗原而产生。
抗原特异性：α(1→3)葡萄糖
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
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Zhou S, et al.
The American Journal of Pathology, 179(2), 890-902 (2011)
Molecular Genetics of Immunoglobulin, 17 (1987)
GATA-1-mediated Transcriptional Repression Yields Persistent Transcription Factor IIB-Chromatin Complexes
Martowicz ML, et al.
The Journal of biological chemistry, 281(49), 37345-37352 (2006)
D Chen et al.
The American journal of physiology, 277(3), H1100-H1106 (1999-09-14)
Abnormal proliferation of vascular smooth muscle cells (VSMCs) is thought to play an important role in the pathogenesis of atherosclerosis and restenosis. Previous studies have implicated the extracellular matrix protein thrombospondin-1 (TSP1) in mitogen-dependent proliferation of VSMCs. In this study
Melissa L Martowicz et al.
The Journal of biological chemistry, 281(49), 37345-37352 (2006-09-12)
The hematopoietic GATA factors GATA-1 and GATA-2, which have distinct and overlapping roles to regulate blood cell development, are reciprocally expressed during erythropoiesis. GATA-1 directly represses Gata2 transcription, and reduced GATA-2 synthesis promotes red blood cell development. Gata2 repression involves
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