M2672
(±)-α-Methyl-(4-tetrazolylphenyl)glycine
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C10H11N5O2
化学文摘社编号:
分子量:
233.23
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
InChI
1S/C10H11N5O2/c1-10(11,9(16)17)7-2-4-8(5-3-7)15-6-12-13-14-15/h2-6H,11H2,1H3,(H,16,17)
SMILES string
CC(N)(C(O)=O)c1ccc(cc1)-n2cnnn2
InChI key
PUQSGMIEFYCTSW-UHFFFAOYSA-N
form
solid
storage temp.
2-8°C
Biochem/physiol Actions
(±)-α-Methyl-(4-tetrazolylphenyl)glycine (MTPG) was used in rat models of cerebral ischemia to explore the role of group II metabotropic glutamate receptors mGluR2/3 in brain ischemia tolerance. MTPG inhibited the induction of ischemia tolerance indicating the involvement of mGluR2/3 in the induction of the protective mechanism.
Potent antagonist for (1S,3S)-ACPD-sensitive receptors; preference for GluR2 and GluR3 subtypes
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Rong-Fang Feng et al.
Sheng li xue bao : [Acta physiologica Sinica], 55(3), 303-310 (2003-06-21)
To explore the role of metabotropic glutamate receptor 2/3 mGluR 2/3 in the induction of brain ischemic tolerance (BIT), the influences of mGluR2/3 antagonist alpha-methyl-(4-tetrazolyl-phenyl) glycine (MTPG) on the induction of BIT and expression of glial fibrillary acidic protein (GFAP)
D E Jane et al.
Neuropharmacology, 34(8), 851-856 (1995-08-01)
The depression of the monosynaptic excitation of neonatal rat motoneurones produced by the metabotropic glutamate receptor (mGluR) agonists (1S,3S)-1-aminocyclopentane-1, 3-dicarboxylate (ACPD) or L-2-amino-4-phosphonobutyrate (L-AP4) was antagonized by three novel phenylglycine analogues: (RS)-alpha-methyl-4-sulphonophenylglycine (MSPG), (RS)-alpha-methyl-4-phosphonophenylglycine (MPPG) and (RS)-alpha-methyl-4-tetrazolylphenylglycine (MTPG). The potencies
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持