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M2699

马立马司他

Name: 马立马司他
Brand: SIGMA

≥98% (HPLC), solid, MMP inhibitor

别名:

BB2516, (2S,3R)-N4- [(1S)-2,2-二甲基-1- [（甲氨基）羰基] 丙基]-N1,2-二羟基-3-（2-甲基丙基）丁二酰胺

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关于此项目

经验公式（希尔记法）:

C₁₅H₂₉N₃O₅

化学文摘社编号:

154039-60-8

分子量:

331.41

UNSPSC Code:

12352200

PubChem Substance ID:

329817950

NACRES:

NA.77

MDL number:

MFCD00866242

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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产品名称

马立马司他, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: ≥20 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C

InChI

1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1

InChI key

OCSMOTCMPXTDND-OUAUKWLOSA-N

Gene Information

—

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Application

Marimastat已用作下列抑制剂：

金属蛋白酶2/9 (MMP2/9)，以研究其对小鼠运动介导的白细胞介素-6 (IL-6)释放的影响
金属蛋白酶，测定铜绿假单胞菌培养物中的蛋白酶活性
金属蛋白酶10 (MMP10)，研究其对结合MMP10的单克隆抗体H3的影响

Biochem/physiol Actions

Marimastat 是一种广谱基质金属蛋白酶 (MMP) 抑制剂

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody.

Amir S Razai et al.

The Journal of biological chemistry, 295(8), 2464-2472 (2020-01-19)

Since their discovery, the matrix metalloproteinase (MMP) family proteases have been considered as therapeutic targets in numerous diseases and disorders. Unfortunately, clinical trials with MMP inhibitors have failed to yield any clinical benefits of these inhibitors. These failures were largely

Stefanie K Menzies et al.

Toxicon: X, 14, 100118-100118 (2022-03-25)

Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom metalloproteinases (SVMPs) consume clotting factors and deplete fibrinogen. The only available treatment

Efficacy and Limitations of Chemically Diverse Small-Molecule Enzyme-Inhibitors against the Synergistic Coagulotoxic Activities of Bitis Viper Venoms.

Nicholas J Youngman et al.

Molecules (Basel, Switzerland), 27(5) (2022-03-11)

Snakebite remains a significant public health burden globally, disproportionately affecting low-income and impoverished regions of the world. Recently, researchers have begun to focus on the use of small-molecule inhibitors as potential candidates for the neutralisation of key snake venom toxins

Towards bioreductively activated prodrugs: Fe(III) complexes of hydroxamic acids and the MMP inhibitor marimastat.

Timothy W Failes et al.

Journal of inorganic biochemistry, 101(3), 396-403 (2007-01-02)

Fe(III)-salen (N,N-bis(salicylidene)-ethane-1,2-diimine) complexes of simple hydroxamic acids and the MMP (matrix metalloproteinase) inhibitor marimastat have been evaluated as hypoxia activated drug carriers. The aceto- (aha), propion- (pha), benzohydroxamato (bha), and marimastat complexes were prepared and characterised by single crystal X-ray

Inhibition of Pseudomonas aeruginosa secreted virulence factors reduces lung inflammation in CF mice.

Angela Sandri et al.

Virulence, 9(1), 1008-1018 (2018-06-26)

Cystic fibrosis (CF) lung infection is a complex condition where opportunistic pathogens and defective immune system cooperate in developing a constant cycle of infection and inflammation. The major pathogen, Pseudomonas aeruginosa, secretes a multitude of virulence factors involved in host

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全球贸易项目编号

货号	GTIN
M2699-25MG	04061833212981
M2699-5MG	04061833212998

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