M2699
马立马司他
≥98% (HPLC), solid, MMP inhibitor
别名:
BB2516, (2S,3R)-N4- [(1S)-2,2-二甲基-1- [（甲氨基）羰基] 丙基]-N1,2-二羟基-3-（2-甲基丙基）丁二酰胺
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关于此项目
经验公式（希尔记法）:
C15H29N3O5
化学文摘社编号:
分子量:
331.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
马立马司他, ≥98% (HPLC)
SMILES string
CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
InChI key
OCSMOTCMPXTDND-OUAUKWLOSA-N
InChI
1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
assay
≥98% (HPLC)
form
solid
solubility
DMSO: ≥20 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
—
Application
Marimastat已用作下列抑制剂：
- 金属蛋白酶2/9 (MMP2/9)，以研究其对小鼠运动介导的白细胞介素-6 (IL-6)释放的影响
- 金属蛋白酶，测定铜绿假单胞菌培养物中的蛋白酶活性
- 金属蛋白酶10 (MMP10)，研究其对结合MMP10的单克隆抗体H3的影响
Biochem/physiol Actions
Marimastat 是一种广谱基质金属蛋白酶 (MMP) 抑制剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Amir S Razai et al.
The Journal of biological chemistry, 295(8), 2464-2472 (2020-01-19)
Since their discovery, the matrix metalloproteinase (MMP) family proteases have been considered as therapeutic targets in numerous diseases and disorders. Unfortunately, clinical trials with MMP inhibitors have failed to yield any clinical benefits of these inhibitors. These failures were largely
Stefanie K Menzies et al.
Toxicon: X, 14, 100118-100118 (2022-03-25)
Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom metalloproteinases (SVMPs) consume clotting factors and deplete fibrinogen. The only available treatment
Brian P Pollack et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(13), 4400-4413 (2011-05-19)
Diverse immune-related effects occur with the use of epidermal growth factor receptor inhibitors (EGFRI). In addition to the cutaneous inflammation induced by EGFRIs, these agents have been associated with the exacerbation of autoimmune skin disease and contact hypersensitivity, antiviral effects
Timothy W Failes et al.
Journal of inorganic biochemistry, 101(3), 396-403 (2007-01-02)
Fe(III)-salen (N,N-bis(salicylidene)-ethane-1,2-diimine) complexes of simple hydroxamic acids and the MMP (matrix metalloproteinase) inhibitor marimastat have been evaluated as hypoxia activated drug carriers. The aceto- (aha), propion- (pha), benzohydroxamato (bha), and marimastat complexes were prepared and characterised by single crystal X-ray
Vincent E de Meijer et al.
PloS one, 5(6), e11256-e11256 (2010-07-02)
Liver fibrosis is characterized by excessive synthesis of extracellular matrix proteins, which prevails over their enzymatic degradation, primarily by matrix metalloproteinases (MMPs). The effect of pharmacological MMP inhibition on fibrogenesis, however, is largely unexplored. Inflammation is considered a prerequisite and
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