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Merck
CN

M2892

Sigma-Aldrich

Methylphenidate hydrochloride

CNS stimulant

别名:

threo-Methyl α-phenyl-α-(2-piperidyl)acetate hydrochloride, Ritalin hydrochloride

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关于此项目

经验公式（希尔记法）:
C14H19NO2 · HCl
化学文摘社编号:
298-59-9
分子量:
269.77
EC 号:
206-065-3
MDL编号:
MFCD00058191
UNSPSC代码:
41116107
PubChem化学物质编号:
24896775
NACRES:
NA.77

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产品名称

Methylphenidate hydrochloride,

描述

Drug Control: Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

质量水平

200

药品控制

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

应用

forensics and toxicology

创始人

Johnson & Johnson

SMILES字符串

Cl[H].COC(=O)C(C1CCCCN1)c2ccccc2

InChI

1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H

InChI key

JUMYIBMBTDDLNG-UHFFFAOYSA-N

基因信息

human ... SLC6A2(6530), SLC6A3(6531)

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相关类别

生化/生理作用

CNS stimulant; releases catecholamines; potent inhibitor of dopamine reuptake

特点和优势

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000456030
0000456029
0000456030
0000456029
0000433619

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Robert Lew et al.
Psychopharmacology, 237(11), 3435-3446 (2020-08-20)
Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would
R Kuczenski et al.
The Journal of pharmacology and experimental therapeutics, 296(3), 876-883 (2001-02-22)
The prescribed use of methylphenidate (Ritalin) in the treatment of attention deficit hyperactivity disorder has risen dramatically in recent years. The relative roles of dopamine, norepinephrine, and serotonin in the therapeutic action of these drugs was assessed by comparing the
Natalia del Campo et al.
Brain : a journal of neurology, 136(Pt 11), 3252-3270 (2013-10-29)
Through the combined use of (18)F-fallypride positron emission tomography and magnetic resonance imaging this study examined the neural mechanisms underlying the attentional deficits associated with attention deficit/hyperactivity disorder and their potential reversal with a single therapeutic dose of methylphenidate. Sixteen
Yvonne Groen et al.
PloS one, 8(3), e59240-e59240 (2013-04-05)
Current models of ADHD suggest abnormal reward and punishment sensitivity, but the exact mechanisms are unclear. This study aims to investigate effects of continuous reward and punishment on the processing of performance feedback in children with ADHD and the modulating
S van der Oord et al.
Journal of attention disorders, 18(8), 699-712 (2012-08-11)
This pilot study tested the short- and long-term efficacy (9 weeks follow-up) of an executive functioning (EF) remediation training with game elements for children with ADHD in an outpatient clinical setting, using a randomized controlled wait-list design. Furthermore, in a
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