M2901
吗多明
别名:
N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10
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经验公式（希尔记法）:
C9H14N4O4
化学文摘社编号:
分子量:
242.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
247-207-4
MDL number:
storage temp.
2-8°C
SMILES string
CCOC(=O)N=C1O[N-][N+](=C1)N2CCOCC2
InChI
1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3/b10-8-
InChI key
XLFWDASMENKTKL-NTMALXAHSA-N
Application
Biochem/physiol Actions
Molsidomine is an effective vasodilator and a long-lasting nitric oxide (NO) donor. It is a pro-drug that is enzymatically decarboxylated to form 3-morpholinosydnone imine (SIN-1) in the liver. Molsidomine is used as an anti-anginal agent and possesses antioxidant properties. It may be used to treat cisplatin-induced oxidative stress in the liver tissue. Molsidomine has also been used during angina pectoris, heart failure, and after myocardial infarction.
Orally active, long acting vasodilator; antianginal; converted by the liver to the active metabolite, SIN-1
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