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Merck
CN

M2939

甲基花生四烯酸氟磷酸酯

≥98%, calcium-dependent and calcium-independent cytosolic phospholipase A2 inhibitor, methyl acetate solution (10 mg/mL)

别名:

MAPF, 甲基-5Z,8Z,11Z,14Z-二十碳四烯酸酯

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关于此项目

经验公式(希尔记法):
C21H36FO2P
化学文摘社编号:
分子量:
370.48
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106300
EC Number:
201-185-2
MDL number:
Assay:
≥98%
Form:
methyl acetate solution (10 mg/mL)
Quality level:
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产品名称

甲基花生四烯酸氟磷酸酯, ≥98%, methyl acetate solution (10 mg/mL)

Quality Level

assay

≥98%

form

methyl acetate solution (10 mg/mL)

shipped in

dry ice

storage temp.

−70°C

SMILES string

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC

InChI

1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-

InChI key

KWKZCGMJGHHOKJ-ZKWNWVNESA-N

Biochem/physiol Actions

MAFP 是一种选择性、不可逆的钙依赖性和非钙依赖性胞浆型磷脂酶 a 2 抑制剂,但不是分泌型磷脂酶 a 2 。MAFP 也是一种强效乙酰胆碱酯酶抑制剂。

Preparation Note

为了更改溶剂,在温和的氮气流下蒸发乙酸甲酯,并立即加入选择的溶剂。

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

3.2 °F - closed cup

flash_point_c

-16 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

危险化学品

此项目有


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Bioorganic chemistry, 79, 98-106 (2018-05-09)
Ghrelin is a small peptide hormone that undergoes a unique posttranslational modification, serine octanoylation, to play its physiological roles in processes including hunger signaling and glucose metabolism. Ghrelin O-acyltransferase (GOAT) catalyzes this posttranslational modification, which is essential for ghrelin to
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The serine hydrolase monoacylglycerol lipase (MAGL) is the rate-limiting enzyme responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) into arachidonic acid and glycerol. Inhibition of 2-AG degradation leads to elevation of 2-AG, the most abundant endogenous agonist of the
Prosanta K Singha et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 149, 105321-105321 (2020-04-11)
De novo synthesis of fatty acids is essential to maintain intensive proliferation of cancer cells. Unlike normal cells that utilize food-derived circulating lipids for their fuel, cancer cells rely on heightened lipogenesis irrespective of exogenous lipid availability. Overexpression and activity

全球贸易项目编号

货号GTIN
M2939-5MG04061838064844

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