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M2949

MDL 72527

Name: MDL 72527
Brand: SIGMA

≥98% (HPLC), spermine oxidase SMO inhibitor, powder

别名:

CPC-200, MDL-72527DA, N,N′-双(2,3-丁二烯基)-1,4-丁二胺二盐酸盐, N1,N4-二(丁-2,3-二烯-1-基)丁烷-1,4-二胺二盐酸盐盐酸盐

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关于此项目

经验公式（希尔记法）:

C₁₂ H₂₀ N₂·2 HCl

化学文摘社编号:

93565-01-6

分子量:

265.22

UNSPSC Code:

12352200

PubChem Substance ID:

329817958

NACRES:

NA.77

MDL number:

MFCD13152261

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

MDL 72527, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

H₂O: 15 mg/mL, clear

storage temp.

room temp

SMILES string

Cl.Cl.C=C=CCNCCCCNCC=C=C

InChI

1S/C12H20N2.2ClH/c1-3-5-9-13-11-7-8-12-14-10-6-4-2;;/h5-6,13-14H,1-2,7-12H2;2*1H

InChI key

ITVRWVVFVHINOH-UHFFFAOYSA-N

说明

Biochem/physiol Actions

MDL 72527是多胺氧化酶（精胺氧化酶SMO）的一种抑制剂。

MDL 72527是多胺氧化酶（精胺氧化酶SMO）的一种抑制剂。它阻止了H2O2的产生并增加了细胞的存活率。多胺分解代谢通常是前列腺细胞产生ROS的主要原因之一，尤其是在雄激素依赖型CaP细胞中雄激素诱导的ROS增强。报告表明前列腺癌的雄激素刺激会导致ROS积聚，从而导致癌症进展，而这种进展是由MDL 72527控制的。

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000540193

0000451496

0000348795

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Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7beta-hydroxycholesterol and 7beta-hydroxysitosterol.

Stamatiki Roussi et al.

International journal of oncology, 29(6), 1549-1554 (2006-11-08)

7beta-OHsitosterol and 7beta-OHcholesterol are natural compounds of plant and animal cells with high structural similarity. Recently it was reported that both compounds induced apoptosis on human colon cancer cells by targeting different signalling pathways. Our study aimed at comparing their

The polyamine oxidase inactivator MDL 72527.

Nikolaus Seiler et al.

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 59, 1-40 (2002-12-03)

Polyamine oxidase is a FAD-dependent amine oxidase, which is constitutively expressed in nearly all tissues of the vertebrate organism. In 1985, N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL 72527) was designed as a selective enzyme-activated irreversible inhibitor of polyamine oxidase (EC 1.5.3.11). It inactivates, at

Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.

Enzo Agostinelli et al.

International journal of oncology, 35(3), 485-498 (2009-07-30)

It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than their wild-type counterparts to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine. The metabolites formed by BSAO and spermine

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全球贸易项目编号

货号	GTIN
M2949-5MG	04061832722870
M2949-25MG	04061832722863