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Merck
CN

M2949

MDL 72527

≥98% (HPLC), spermine oxidase SMO inhibitor, powder

别名:

CPC-200, MDL-72527DA, N,N′-双(2,3-丁二烯基)-1,4-丁二胺 二盐酸盐, N1,N4-二(丁-2,3-二烯-1-基)丁烷-1,4-二胺二盐酸盐 盐酸盐

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关于此项目

经验公式(希尔记法):
C12 H20 N2·2 HCl
化学文摘社编号:
分子量:
265.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
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产品名称

MDL 72527, ≥98% (HPLC)

SMILES string

Cl.Cl.C=C=CCNCCCCNCC=C=C

InChI key

ITVRWVVFVHINOH-UHFFFAOYSA-N

InChI

1S/C12H20N2.2ClH/c1-3-5-9-13-11-7-8-12-14-10-6-4-2;;/h5-6,13-14H,1-2,7-12H2;2*1H

assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

H2O: 15 mg/mL, clear

storage temp.

room temp

Quality Level

Biochem/physiol Actions

MDL 72527是多胺氧化酶(精胺氧化酶SMO)的一种抑制剂。
MDL 72527是多胺氧化酶(精胺氧化酶SMO)的一种抑制剂。它阻止了H2O2的产生并增加了细胞的存活率。多胺分解代谢通常是前列腺细胞产生ROS的主要原因之一,尤其是在雄激素依赖型CaP细胞中雄激素诱导的ROS增强。报告表明前列腺癌的雄激素刺激会导致ROS积聚,从而导致癌症进展,而这种进展是由MDL 72527控制的。

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Yoshiko Mitsuya et al.
Journal of plant physiology, 164(6), 785-793 (2006-08-03)
In a previous work, we identified a Cys(2)/His(2)-type zinc-finger transcription repressor, (ZFT1), that functions in a spermine-mediated signal transduction pathway in tobacco plants. Database search disclosed the presence of another Cys(2)/His(2)-type zinc-finger protein ZFP1 (accession number AAC06243) in tobacco plants.
Tianyun Wu et al.
Biochemical and biophysical research communications, 326(2), 483-490 (2004-12-08)
Murine N(1)-acetylated polyamine oxidase (mPAO) was treated with N,N'-bis-(prop-2-ynyl)-1,4-diaminobutane, a poor substrate and inhibitor for the enzyme, with K(m) and K(i) values in the millimolar range. Apparently, its oxidation produces prop-2-ynal, which reacts with amino acyl nucleophiles. Using a steady-state
Francine Gossé et al.
International journal of oncology, 29(2), 423-428 (2006-07-06)
Apple procyanidins have chemopreventive properties in a model of colon cancer, they affect intracellular signalling pathways, and trigger apoptosis in a human adenocarcinoma-derived metastatic cell line (SW620). In the present study we investigated relationships between procyanidin-induced alterations in polyamine metabolism
Enzo Agostinelli et al.
Biochemical and biophysical research communications, 340(3), 840-844 (2005-12-29)
MDL 72527 was considered a selective inhibitor of FAD-dependent polyamine oxidases. In the present communication, we demonstrate that MDL 72527 inactivates bovine serum amine oxidase, a copper-containing, TPQ-enzyme, time-dependently at 25 degrees C. In striking contrast, the enzyme remained active
S M Oredsson et al.
Biochemical Society transactions, 35(Pt 2), 405-409 (2007-03-21)
Reduction of cellular polyamine pools results in inhibition of cell proliferation and sometimes in induction of cell death. Reduction of cellular polyamine pools can be achieved by several strategies involving all the mechanisms of polyamine homoeostasis, i.e. biosynthesis, catabolism and

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