M3071
吗氯贝胺
≥98% (HPLC), MAOI inhibitor, solid
别名:
4-氯-N-[2-(4-吗啉基)乙基]苯甲酰胺, 吗氯贝胺
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关于此项目
经验公式（希尔记法）:
C13H17ClN2O2
化学文摘社编号:
分子量:
268.74
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
吗氯贝胺, ≥98% (HPLC), solid
SMILES string
Clc1ccc(cc1)C(=O)NCCN2CCOCC2
InChI key
YHXISWVBGDMDLQ-UHFFFAOYSA-N
InChI
1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: >20 mg/mL
originator
Roche
storage temp.
room temp
Quality Level
Biochem/physiol Actions
吗氯贝胺可作为细胞色素P450 2C19（CYP2C19）的底物。它也可充当细胞色素P450 2D6（CYP2D6）、细胞色素P450 1A2（CYP1A2和CYP2C19）的抑制剂。吗氯贝胺还和B细胞淋巴瘤2（BcL-2）表达的增加有关。它还通过胞外调节激酶（ERK）途径使神经干细胞（NSC）分化为血清素能神经元（serotoninergic neuron）。
吗氯贝胺是一种可逆性单胺氧化酶A抑制剂（MAOI）； 抗抑郁药。
吗氯贝胺是一种可逆性单胺氧化酶A抑制剂（MAOI）； 抗抑郁药。人体内的消除半衰期= 1 -3小时；绝对口服生物利用度。与其他MAO抑制剂不同，它与酪胺合用不会显著增加人的血压。
Features and Benefits
该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面， 请单击此处。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Zdenek Fisar et al.
Neuro endocrinology letters, 31(5), 645-656 (2011-01-05)
Monoamine oxidase (MAO), the enzyme responsible for metabolism of monoamine neurotransmitters, has an important role in the brain development and function, and MAO inhibitors have a range of potential therapeutic uses. We investigated systematically in vitro effects of pharmacologically different
Anatoly Kreinin et al.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 12(8), 620-626 (2010-10-23)
Previous publications demonstrated substitute benzamides as effective agents in treatment of clozapine-induced sialorrhea (CIS). The aim of this study was to compare efficacy of amisulpride and moclobemide (both from the substitute benzamide group) in controlling, or at least minimizing, CIS.
Ingrid M M van Haelst et al.
The Journal of clinical psychiatry, 73(8), 1103-1109 (2012-09-04)
To investigate the occurrence of intraoperative hemodynamic events when antidepressive treatment with monoamine oxidase inhibitors (MAOIs) was continued during anesthesia. A retrospective observational cohort study was conducted among patients who were admitted for elective surgery requiring anesthesia in 8 Dutch
Shih-Hwa Chiou et al.
British journal of pharmacology, 148(5), 587-598 (2006-05-17)
1. Moclobemide (MB) is an antidepressant drug that selectively and reversibly inhibits monoamine oxidase-A. Recent studies have revealed that antidepressant drugs possess the characters of potent growth-promoting factors for the development of neurogenesis and improve the survival rate of serotonin
P Bech et al.
Journal of affective disorders, 140(3), 253-259 (2012-03-03)
To investigate to what extent the primary depression subtype atypical depression can predict differential outcome of the mono-amino-oxidase inhibitor (MAO-I) moclobemide and the tricyclic antidepressant clomipramine in the Danish University Antidepressant Group Study (DUAG). In a randomised, double blind trial
商品
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。
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