M3184
MG 624
≥98%
别名:
N,N,N-Triethyl-2-(4-trans-stilbenoxy)ethylammonium iodide
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关于此项目
经验公式（希尔记法）:
C22H30INO
化学文摘社编号:
分子量:
451.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98%
Quality level:
产品名称
MG 624, ≥98%
InChI
1S/C22H30NO.HI/c1-4-23(5-2,6-3)18-19-24-22-16-14-21(15-17-22)13-12-20-10-8-7-9-11-20;/h7-17H,4-6,18-19H2,1-3H3;1H/q+1;/p-1/b13-12+;
SMILES string
[I-].CC[N+](CC)(CC)CCOc1ccc(cc1)\C=C\c2ccccc2
InChI key
RDTKUZXIHMTSJO-UEIGIMKUSA-M
assay
≥98%
solubility
DMSO: ≤22 mg/mL
H2O: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... CHRNA7(1139)
Biochem/physiol Actions
Nicotinic acetylcholine receptor antagonist; selectively inhibits neuronal nicotinic α-bungarotoxin sensitive receptors that contain the α7 subunit.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Glenn W Vicary et al.
Respiratory research, 18(1), 115-115 (2017-06-04)
Tobacco-related chronic lung diseases are characterized by alterations in lung architecture leading to decreased lung function. Knowledge of the exact mechanisms involved in tobacco-induced tissue remodeling and inflammation remains incomplete. We hypothesize that nicotine stimulates the expression of extracellular matrix
C Gotti et al.
British journal of pharmacology, 124(6), 1197-1206 (1998-08-28)
1. Starting from the structure of an old 4-oxystilbene derivate with ganglioplegic activity (MG624), we synthesized two further derivates (F2 and F3) and two stereoisomers of F3 (F3A and F3B), and studied their selective effect on neuronal nicotinic acetylcholine receptor
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