M3189
Mepivacaine hydrochloride
98.0-102.0%, meets USP testing specifications
别名:
1-Methyl-2′,6′-pipecoloxylidine hydrochloride, N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride
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关于此项目
经验公式（希尔记法）:
C15H22N2O · HCl
化学文摘社编号:
分子量:
282.81
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
217-023-9
MDL number:
assay
98.0-102.0%
InChI key
RETIMRUQNCDCQB-UHFFFAOYSA-N
InChI
1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H
SMILES string
CN1CCCCC1C(NC2=C(C)C=CC=C2C)=O.Cl
agency
meets USP testing specifications
originator
Novocol
Gene Information
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Biochem/physiol Actions
Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.
Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novocol. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - STOT SE 3
target_organs
Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Jeff Gadsden et al.
Anesthesia and analgesia, 115(4), 963-967 (2012-07-17)
During peripheral nerve blockade, different local anesthetics may be sequentially administered. Typically, a short- or intermediate-acting local anesthetic is administered before a long-acting local anesthetic to achieve a block with rapid onset and long duration. However, there is a paucity
D Van Vynckt et al.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T, 25(4), 307-313 (2012-06-15)
Assessment of the effect of intra-articular anaesthesia on lameness caused by medial coronoid disease. This study included 90 dogs that were evaluated for the complaint of unilateral forelimb lameness. All dogs were suspected of having an elbow problem for which
Hui-Jin Sung et al.
Canadian journal of physiology and pharmacology, 90(7), 863-872 (2012-06-19)
Mepivacaine is an aminoamide-linked local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro. The aims of this in-vitro study were to examine the direct effect of mepivacaine in isolated rat aortic rings and
Mi Hyeon Lee et al.
Pain medicine (Malden, Mass.), 13(11), 1381-1388 (2012-09-28)
Compared with the blind technique, ultrasound-guided stellate ganglion block (SGB) reduces the amount of local anesthetic needed for a successful block. The purpose of this study is to determine the minimal, optimal volume of local anesthetic required for successful ultrasound-guided
Christopher J Snyder et al.
Journal of the American Veterinary Medical Association, 242(2), 199-204 (2013-01-02)
To evaluate the effects of a routinely used infraorbital nerve block, performed for dental procedures, on the anesthetic requirement for isoflurane in dogs. Prospective controlled study. 8 healthy adult Beagles. Dogs were anesthetized with isoflurane, and the minimum alveolar concentration
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