M3199
MK-212 hydrochloride
≥98% (HPLC)
别名:
2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride, 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride, NSC 31732
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关于此项目
经验公式（希尔记法）:
C8H11ClN4·HCl
化学文摘社编号:
分子量:
235.11
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
262-883-0
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
SMILES string
Cl.Clc1cncc(n1)N2CCNCC2
InChI
1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H
InChI key
PFIZGLUIYAZQFU-UHFFFAOYSA-N
Biochem/physiol Actions
Selective 5-HT2C serotonin receptor agonist.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Janet L Neisewander et al.
Behavioural pharmacology, 18(8), 791-800 (2007-11-09)
The extinction/reinstatement model has been used in this study to examine the role of 5-HT2C receptors in cocaine-seeking behavior elicited by cocaine-associated cues and cocaine-priming injections. Rats that had been trained to press a lever for cocaine (0.75 mg/kg/0.1 ml
Nathan S Pentkowski et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(10), 2037-2048 (2010-06-04)
Serotonin 2C receptor (5-HT(2C)R) agonists administered systemically attenuate both cocaine-primed and cue-elicited reinstatement of extinguished cocaine-seeking behavior. To further elucidate the function of these receptors in addiction-like processes, this study examined the effects of microinfusing the 5-HT(2C)R agonist MK212 (0
K S Gomes et al.
Progress in neuro-psychopharmacology & biological psychiatry, 33(7), 1261-1269 (2009-07-25)
A single exposure to the elevated plus-maze test (EPM) increases open arms avoidance and reduces or abolishes the anxiolytic-like effect of benzodiazepines assessed during a second trial, a phenomenon defined as "one-trial tolerance" (OTT). It has been emphasized that the
Antonio Pedro de Mello Cruz et al.
Psychopharmacology, 182(3), 345-354 (2005-09-01)
Although 5-HT2 receptors seem to play an important role in anxiety, results from numerous studies are still highly variable. Moreover, little is known about the behavioral effects of centrally administered 5-HT2 compounds in animal models of anxiety. The current study
Adriane M dela Cruz et al.
Behavioural pharmacology, 20(8), 720-730 (2009-11-11)
Only a subgroup of human drug users progress from initial drug taking to drug addiction. The learned associations between the effects of the drug and the environment in which it is experienced is an important aspect of the progression to
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M3199-25MG | 04061832072203 |
| M3199-5MG | 04061832072210 |
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