M3281
α-甲基-DL-酪氨酸甲酯 盐酸盐
≥95% (HPLC)
别名:
α-MT甲酯 盐酸盐, 2-甲基-4-羟基-DL-苯丙氨酸甲酯 盐酸盐, AMPT盐酸甲酯
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线性分子式:
4-(HO)C6H4CH2C(CH3)(NH2)CO2CH3 · HCl
化学文摘社编号:
分子量:
245.70
Beilstein:
5163031
EC 号:
MDL编号:
UNSPSC代码:
12352108
PubChem化学物质编号:
NACRES:
NA.32
质量水平
方案
≥95% (HPLC)
mp
192 °C (dec.) (lit.)
溶解性
DMSO: ≥20 mg/mL, clear, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
Cl[H].COC(=O)C(C)(N)Cc1ccc(O)cc1
InChI
1S/C11H15NO3.ClH/c1-11(12,10(14)15-2)7-8-3-5-9(13)6-4-8;/h3-6,13H,7,12H2,1-2H3;1H
InChI key
OOVDEPZODSXAMU-UHFFFAOYSA-N
基因信息
human ... TH(7054)
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应用
α-甲基-DL-酪氨酸甲酯盐酸盐已被用于评估去甲肾上腺素的转换。
生化/生理作用
α-甲基-DL-酪氨酸(α-MT)可防止过度活性、嗅舔啃综合征、厌食症并改善苯丙胺的某些作用。它可抑制多巴胺的产生并防止突变体α-突触核蛋白刺激的细胞凋亡。
酪氨酸羟化酶抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Antiamphetamine effects following inhibition of tyrosine hydroxylase
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Dopamine (DA) in the medial preoptic area (MPOA) has been shown to facilitate male rat sexual behavior. However, injections of the catecholamine (CA) neurotoxin 6-OHDA into the MPOA did not impair copulation in tests 3 days after injection. In the
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To further investigate neural effects on leptin and uncoupling proteins (UCPs), we studied in vivo perturbations intended to block adrenergic input to peripheral tissues. We examined plasma leptin, leptin mRNA, and adipose and muscle UCP subtype mRNA in rats treated
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