M3319
Anti-Mint2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Munc-18-1 Interacting Protein 2, Anti-X11β, Anti-X11L
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IP, WB
Citations:
7
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 120 kDa
species reactivity
rat
technique(s)
immunoprecipitation (IP): 5-10 μg using a rat brain extract (S1 fraction)., microarray: suitable, western blot: 0.25-0.5 μg/mL using rat brain extract (S1 fraction)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... APBA2(321)
mouse ... Apba2(11784)
rat ... Apba2(83610)
General description
Munc-18-1 interacting protein 2 (Mint2), also called X11L, shares 50% homology with Mint1 and both are expressed exclusively in brain and bind Munc-18-1 with high affinity. It has N-terminal Munc-18-1-interacting domain (MID), a middle phosphotyrosine-binding (PTB) domain, and two C-terminal PDZ domain. It belongs to mammalian LIN-10 protein family. Mint 2 is present in neurons.
Immunogen
synthetic peptide corresponding to amino acids 1-18, located at the N-terminus of rat mint2, conjugated to KLH. This sequence is highly conserved (single amino acid substitution) in mouse mint2 and shows limited homology (66% identity) to human mint2. It does not share homology with the mint1 and mint3 isoforms.
Application
Anti-Mint2 antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunostaining
Biochem/physiol Actions
Munc-18-1 interacting protein 2 (Mint2) participates in vesicle exocytosis. Mint 2 interacts with amyloid-β precursor protein (APP) and presenilins. It favors phosphorylation of β-amyloid precursor protein family members APP and Amyloid-like protein 2 (APLP2) in response to cellular stress, by facilitating c-Jun N-terminal kinase mediated phosphorylation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein
Taru H and Suzuki T
Test, 279(20), 21628-21636 (2004)
Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms
Biederer T, et al.
The Journal of Neuroscience, 22(17), 7340-7351 (2002)
Intracellular amyloid precursor protein sorting and amyloid-$\beta$ secretion are regulated by Src-mediated phosphorylation of Mint2
Chaufty J, et al.
The Journal of Neuroscience, 32(28), 9613-9625 (2012)
Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid $\beta$ generation
Sullivan S, et al.
The Journal of Biological Chemistry, 289(22), 15374-15383 (2014)
Amy Y Lin et al.
Scientific reports, 9(1), 6024-6024 (2019-04-17)
MINT2/APBA2 is a synaptic adaptor protein involved in excitatory synaptic transmission. Several nonsynonymous coding variants in MINT2 have been identified in autism spectrum disorders (ASDs); however, these rare variants have not been examined functionally and the pathogenic mechanisms are unknown.
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