M3324
M100907
≥98% (HPLC), 5-HT2A Antagonist, powder
别名:
(R)-(+)-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基]-4-吡啶甲醇, MDL100907, 诺和灵
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关于此项目
经验公式（希尔记法）:
C22H28FNO3
化学文摘社编号:
分子量:
373.46
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
M100907, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
off-white to light brown
溶解性
DMSO: ≥20 mg/mL
储存温度
2-8°C
SMILES字符串
COc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC
InChI
1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1
InChI key
HXTGXYRHXAGCFP-OAQYLSRUSA-N
基因信息
human ... HTR2A(3356)
相关类别
一般描述
M100907 可阻断血清素 2A (5-HT2A) 受体并产生抗抑郁作用。它可用于治疗多巴胺能异常。
生化/生理作用
M100907 是一种选择性 5-HT2A 拮抗剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Mona E Hervig et al.
Psychology & neuroscience, 13(3), 438-458 (2021-02-23)
Adapting behavior to a dynamic environment requires both steadiness when the environment is stable and behavioral flexibility in response to changes. Much evidence suggests that cognitive flexibility, which can be operationalized in reversal learning tasks, is mediated by cortico-striatal circuitries
Ashley Furr et al.
The international journal of neuropsychopharmacology, 15(9), 1295-1305 (2011-10-20)
Chronic stress is a risk factor for depression, and chronic stress can induce cognitive impairments associated with prefrontal cortical dysfunction, which are also major components of depression. We have previously shown that 5 wk chronic intermittent cold (CIC) stress induced
Kerry A Waters et al.
Behavioural brain research, 228(1), 211-218 (2011-12-23)
The 5-hydroxytryptamine7 (5-HT7) receptor is a G-protein coupled receptor for serotonin that has been implicated in the pathophysiology of psychiatric and neurological disorders including anxiety, depression and schizophrenia. A number of studies have attempted to evaluate the potential role of
Paul J Fletcher et al.
Neuropharmacology, 61(3), 468-477 (2011-03-16)
Previous work has shown that 5-HT(2C) receptor agonists and 5-HT(2A) receptor antagonists reduce impulsive action, as well as the locomotor stimulant effect of psychomotor stimulants. Since psychomotor stimulants also increase impulsive action we examined the effects of the 5-HT(2C) receptor
Lara A Pockros et al.
Psychopharmacology, 213(2-3), 307-320 (2010-11-17)
The action of serotonin (5-HT) at the 5-HT(2A) receptor subtype is thought to be involved in cocaine-seeking behavior that is motivated by exposure to drug-associated cues and drug priming. 5-HT(2A) receptors are densely clustered in the ventromedial prefrontal cortex (vmPFC)
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