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M3324

M100907

Name: M100907
Brand: SIGMA

≥98% (HPLC), 5-HT2A Antagonist, powder

别名:

(R)-(+)-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基]-4-吡啶甲醇, MDL100907, 诺和灵

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₈FNO₃

化学文摘社编号:

139290-65-6

分子量:

373.46

UNSPSC Code:

12352200

PubChem Substance ID:

329817971

NACRES:

NA.77

MDL number:

MFCD00909060

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

M100907, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

off-white to light brown

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

COc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC

InChI

1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1

InChI key

HXTGXYRHXAGCFP-OAQYLSRUSA-N

Gene Information

human ... HTR2A(3356)

说明

General description

M100907 可阻断血清素 2A (5-HT2A) 受体并产生抗抑郁作用。它可用于治疗多巴胺能异常。

Biochem/physiol Actions

M100907 是一种选择性 5-HT2A 拮抗剂。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction.

Kathryn A Cunningham et al.

ACS chemical neuroscience, 4(1), 110-121 (2013-01-22)

Relapse to cocaine dependence, even after extended abstinence, involves a number of liability factors including impulsivity (predisposition toward rapid, unplanned reactions to stimuli without regard to negative consequences) and cue reactivity (sensitivity to cues associated with cocaine-taking which can promote

The selective 5-HT 2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine

Marek GJ, et al.

Neuropsychopharmacology, 30(12), 2205-2205 (2005)

Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement.

Paul J Fletcher et al.

Neuropharmacology, 62(7), 2288-2298 (2012-02-22)

The reinforcing effects of nicotine are mediated in part by brain dopamine systems. Serotonin, acting via 5-HT(2A) and 5-HT(2C) receptors, modulates dopamine function. In these experiments we examined the effects of the 5-HT(2C) receptor agonist Ro60-0175 and the 5-HT(2A) receptor

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全球贸易项目编号

货号	GTIN
M3324-25MG	04061832072227
M3324-5MG	04061834050131