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Merck
CN

M3445

厚朴酚

≥90% (HPLC), from plant

别名:

2,2′-双香豆素, 5,5′-Diallyl-2,2′-biphenyldiol

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关于此项目

经验公式（希尔记法）:
C18H18O2
化学文摘社编号:
528-43-8
分子量:
266.33
NACRES:
NA.25
PubChem Substance ID:
24896843
UNSPSC Code:
12352100
MDL number:
MFCD00016658

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产品名称

厚朴酚, ≥90% (HPLC), from plant

InChI

1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2

SMILES string

Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O

InChI key

VVOAZFWZEDHOOU-UHFFFAOYSA-N

biological source

plant

assay

≥90% (HPLC)

solubility

ethanol: soluble 1 mg/mL
methanol: soluble 1.5 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
fungi

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

mode of action

cell membrane | interferes

storage temp.

2-8°C

Quality Level

200

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相关类别

Application

厚朴酚已被用于：
  • 检测其对肌少症小鼠肌肉萎缩及巨噬细胞亚型的影响
  • 在血管生成实验中检测其对人脐静脉内皮细胞(HUVEC)的抑制作用
  • 检测其对念珠菌生长、超微结构和生物膜形成的抑制作用
  • 制备固定化氨基功能化介孔二氧化硅颗粒，以进行缓释研究

Biochem/physiol Actions

厚朴酚具有抗抑郁和神经退行性。它还被认为是一种有效的抗癌药物，参与减少细胞增殖，细胞毒性和诱导细胞凋亡。
厚朴酚是从木兰科植物 厚朴的根和茎皮中分离得到的一种具有生物活性的植物成分 ，具有抗真菌、 抗菌 和抗氧化作用。厚朴酚还通过干扰 NF-κ 而显示抗炎活性 B 信号传导。由于其能够抑制 IL-6 诱导的 STAT3 活化，因此其似乎也具有与血管疾病（如动脉粥样硬化）相关的抗炎属性。

General description

厚朴酚是从不同中草药厚朴的根和茎皮中提取的一种具有生物活性的新木质素。它具有羟基化的双酚结构，类似于其结构异构体厚朴酚。它是一种亲脂化合物。

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000492394
0000492394
0000382356
0000370746
0000336873

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膳食抗氧化剂

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