M3509
β,γ-亚甲基鸟苷 5′-三磷酸 钠盐
≥98% (HPLC), synthetic (organic), powder
别名:
GMPPCP, GppCp, 鸟苷-5′-[β,γ-亚甲基]三磷酸 钠盐
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关于此项目
经验公式（希尔记法）:
C11H18N5O13P3 · xNa+
化学文摘社编号:
分子量:
521.21 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
Assay:
≥98% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
产品名称
β,γ-亚甲基鸟苷 5′-三磷酸 钠盐, ≥98% (HPLC)
SMILES string
[Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(=O)CP(O)(O)=O)C(O)C3O)c2N1
InChI
1S/C11H18N5O13P3.Na.H/c12-11-14-8-5(9(19)15-11)13-2-16(8)10-7(18)6(17)4(28-10)1-27-32(25,26)29-31(23,24)3-30(20,21)22;;/h2,4,6-7,10,17-18H,1,3H2,(H,23,24)(H,25,26)(H2,20,21,22)(H3,12,14,15,19);;
InChI key
LJQPGKRRFLMZPX-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
Application
βγ-亚甲基鸟苷 5′-三磷酸 (GMPPCP, GppCp) 是不可水解的GTP类似物，可用于涉及GTP结合的各种应用，包括GTP活化、GTP抑制、GTP转运、GTP水解和GTP结构稳定化。GMPPCP (GuoPP[CH2MP) 可用于调节和研究参与细胞信号传导、蛋白质合成和其他代谢过程的G蛋白。
β,γ-亚甲基鸟苷 5′-三磷酸钠盐已被用作GTP类似物，用于与发动蛋白络合进行冷冻电子显微镜分析。它还被用于与Di-Ras1/Di-Ras2络合，用于核苷酸交换递送研究。
Biochem/physiol Actions
βγ-亚甲基鸟苷 5′-三磷酸 (GMPPCP) 可用于涉及GTP结合的各种应用，包括GTP活化、GTP抑制、GTP转运、GTP水解和GTP结构稳定化。GMPPCP可用于调节和研究参与细胞信号传导、蛋白质合成和其他代谢过程的G蛋白。
General description
βγ-亚甲基鸟苷5′-三磷酸 (GMPPCP, GppCp) 是不可水解的GTP类似物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Gilles Labesse et al.
Nucleic acids research, 39(8), 3458-3472 (2010-12-15)
Nucleoside Monophosphate Kinases (NMPKs) family are key enzymes in nucleotide metabolism. Bacterial UMPKs depart from the main superfamily of NMPKs. Having no eukaryotic counterparts they represent attractive therapeutic targets. They are regulated by GTP and UTP, while showing different mechanisms
Structural inhibition of dynamin-mediated membrane fission by endophilin
Hohendahl A, et al.
eLife, 6, e26856-e26856 (2017)
T Schweins et al.
Journal of molecular biology, 266(4), 847-856 (1997-03-07)
GTP and ATP hydrolysing proteins have an absolute requirement for a divalent cation, which is usually Mg2+, as a cofactor in the enzymatic reaction. Other phosphoryl transfer enzymes employ more than one divalent ion for the enzymatic reaction. It is
Ravi Kiran Koripella et al.
Nature communications, 11(1), 3830-3830 (2020-08-02)
The mammalian mitochondrial ribosome (mitoribosome) and its associated translational factors have evolved to accommodate greater participation of proteins in mitochondrial translation. Here we present the 2.68-3.96 Å cryo-EM structures of the human 55S mitoribosome in complex with the human mitochondrial elongation
Sandro F Ataide et al.
Science (New York, N.Y.), 331(6019), 881-886 (2011-02-19)
Cotranslational targeting of membrane and secretory proteins is mediated by the universally conserved signal recognition particle (SRP). Together with its receptor (SR), SRP mediates the guanine triphosphate (GTP)-dependent delivery of translating ribosomes bearing signal sequences to translocons on the target
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