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About This Item

经验公式(希尔记法):
C17H20O6
CAS Number:
分子量:
320.34
Beilstein:
1295848
EC 号:
MDL编号:
UNSPSC代码:
12352207
PubChem化学物质编号:
NACRES:
NA.76
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Product Name

霉酚酸, powder, BioReagent, suitable for cell culture

生物来源

Penicillium brevicompactum

质量水平

产品线

BioReagent

表单

powder

技术

cell culture | mammalian: suitable

颜色

white to yellow-white

mp

<143.0 °C

溶解性

methanol: 50 mg/mL

作用机制

enzyme | inhibits

储存温度

2-8°C

SMILES字符串

COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O

InChI

1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+

InChI key

HPNSFSBZBAHARI-RUDMXATFSA-N

基因信息

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应用

Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL.

生化/生理作用

作用方式:本品通过抑制细胞因子诱导的一氧化氮生成,抑制嘌呤核苷酸的早期生物合成,并作为 IMP 脱氢酶的特异性抑制剂发挥作用。

注意

As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.

制备说明

Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral

靶器官

Immune system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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