M3568
MSX-3 水合物
≥98% (HPLC), solid
别名:
3,7-二氢-8-[(1E)-2-(3-甲氧基苯基)乙烯基]-7-甲基-3- [3-(膦酰氧基)丙基-1-(2-丙炔基)-1H-嘌呤-2,6-二酮 二钠盐 水合物
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选择尺寸
关于此项目
经验公式(希尔记法):
C21H21N4O7PNa2 · xH2O
化学文摘社编号:
分子量:
518.37 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
颜色
pale yellow
溶解性
H2O: soluble >5 mg/mL at 60 °C
储存温度
−20°C
SMILES字符串
O.[Na+].[Na+].COc1cccc(\C=C\c2nc3N(CCCOP([O-])([O-])=O)C(=O)N(CC#C)C(=O)c3n2C)c1
InChI
1S/C21H23N4O7P.2Na.H2O/c1-4-11-25-20(26)18-19(24(21(25)27)12-6-13-32-33(28,29)30)22-17(23(18)2)10-9-15-7-5-8-16(14-15)31-3;;;/h1,5,7-10,14H,6,11-13H2,2-3H3,(H2,28,29,30);;;1H2/q;2*+1;/p-2/b10-9+;;;
InChI key
FANGYFUIIWHEAQ-WCVSPGPUSA-L
一般描述
逐渐升温 10 分钟即可溶解。刚配制的溶液可能略不透明。
生化/生理作用
选择性 A2A 腺苷受体拮抗剂前药。
免责声明
光敏和气敏
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
W Hauber et al.
Neuroreport, 9(8), 1803-1806 (1998-07-17)
Motor effects mediated through adenosine A2A receptors within the caudate-putamen were investigated in rats using bilateral microinfusions of MSX-3 (9 microg in 1 microl per side), a water-soluble phosphate prodrug of the selective A2A receptor antagonist MSX-2. Blockade of striatal
Monique A Spillman et al.
Cancer research, 70(21), 8927-8936 (2010-10-21)
Menopausal estrogen (E2) replacement therapy increases the risk of estrogen receptor (ER)-positive epithelial ovarian cancers (EOC). Whether E2 is tumorigenic or promotes expansion of undiagnosed preexisting disease is unknown. To determine E2 effects on tumor promotion, we developed an intraperitoneal
R Sauer et al.
Journal of medicinal chemistry, 43(3), 440-448 (2000-02-12)
Water-soluble prodrugs of potent, A(2A)-selective adenosine receptor (AR) antagonists were prepared. 8-(m-Bromostyryl)-3, 7-dimethyl-1-propargylxanthine (BS-DMPX, 11) and the analogous 8-(m-methoxystyryl)xanthine derivative (MS-DMPX, 5b) were used as starting points. It was found that polar functional groups suitable for the attachment of a
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