M3763
腺苷 5′ -(α,β-亚甲基)二磷酸
≥99% (HPLC), synthetic (organic), powder
别名:
α,β-亚甲基腺苷 5′-二磷酸, ADP[α,β-CH2], AMP-CP
Product Name
腺苷 5′ -(α,β-亚甲基)二磷酸, ADP analog
生物来源
synthetic (organic)
质量水平
方案
≥99% (HPLC)
表单
powder
溶解性
water: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]3O
InChI
1S/C11H17N5O9P2/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1
InChI key
OLCWZBFDIYXLAA-IOSLPCCCSA-N
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相关类别
应用
5′-(α,β-亚甲基)二磷酸腺苷可作为培养基组分,用于研究其对于CD73或调节胞外-5′-核苷酸酶介导的分化簇73(CD73)和腺苷能信号传导调控的抑制作用。
制备说明
加热后可溶于水,最高约 50 mg/ml
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
CD73 Regulates stemness and epithelial-mesenchymal transition in ovarian cancer-initiating cells
Lupia M, et al.
Stem Cell Reports, 10(4), 1412-1425 (2018)
L Jensen et al.
Angiogenesis, 7(3), 255-267 (2004-12-21)
The role of muscle contraction, prostanoids, nitric oxide and adenosine in the regulation of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and endothelial cell proliferative compounds in skeletal muscle cell cultures was examined. VEGF and bFGF mRNA
Svetlana T Mihaylova-Todorova et al.
The Journal of pharmacology and experimental therapeutics, 302(3), 992-1001 (2002-08-17)
Previously, we have demonstrated that stimulation of the sympathetic nerves of the guinea pig vas deferens evokes release not only of the cotransmitters ATP and norepinephrine but also of soluble nucleotidases that break down extracellular ATP, ADP, and AMP into
J Karczewska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 58(2), 321-333 (2007-07-12)
ATP and adenosine are important extracellular regulators of glomerular functions. In this study, ATP release from glomeruli suspension and its extracellular metabolism were investigated. Basal extraglomerular ATP concentration (1nM) increased several fold during inhibition of ecto-ATPase activity, reflecting the basal
TGFbeta-induced osteogenic potential of human amniotic fluid stem cells via CD73-generated adenosine production
Hau KL, et al.
Scientific Reports, 7(1) (2017)
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