产品名称
IgM, Kappa 来源于鼠骨髓瘤, clone TEPC 183, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
TEPC 183, monoclonal
assay
≥90% (HPLC)
form
buffered aqueous solution
concentration
2.0-2.2 mg/mL
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
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相关类别
Application
来自小鼠骨髓瘤的IgM, Kappa已被用于：
- 夹心法酶联免疫吸附试验 (ELISA)
- 流式细胞术
- 斑点免疫结合试验
Biochem/physiol Actions
IgM在凋亡细胞的吞噬中起关键作用。血清IgM水平降低会导致自身免疫反应增强，并增加感染风险。IgM显示出多反应和自动反应功能。它可通过介导基于组织的分子的清除在组织动态平衡中起关键作用。IgM具有与N-连接的糖基化位点，其中糖是甘露糖、半乳糖、N-乙酰氨基葡萄糖和唾液酸。IgM连接的琼脂糖树脂经检测是有效的结合物结合。
TEPC 183肿瘤细胞系来源于原始诱导的浆细胞瘤，并在BALB/c小鼠皮下携带。TEPC 183细胞系的半抗原结合特异性尚未确定。它可特异性识别小鼠IgM。免疫球蛋白的识别性和纯度可通过免疫电泳进行确定。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
IgM抗体以五聚体的形式存在于血清中，其是通过对抗原的反应而产生的来源于鼠骨髓瘤的IgM, κ是由BAPC/c小鼠皮下注入的TEPC 183肿瘤细胞系产生的。
IgM是一种脊椎动物中高度保守的抗体，在免疫应答过程中早期表达。它是由腹膜B细胞分泌的。
通过280 nm (E1%/280 = 11.8)处吸光度测定含量，每瓶含有至少1 mg纯化骨髓瘤蛋白。
Physical form
溶于含有0.05 M Tris(pH 8.0)、0.5 M氯化钠、0.02%叠氮化钠的溶液中
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
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