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M4069

微囊藻素 YR 来源于铜绿微囊藻菌

cyanotoxin

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关于此项目

经验公式（希尔记法）:
C52H72N10O13
化学文摘社编号:
101064-48-6
分子量:
1045.19
UNSPSC Code:
12352202
PubChem Substance ID:
24896901
MDL number:
MFCD00236437
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biological source

microbial (Microcystis aerguinosa)

Quality Level

200

assay

≥90% (HPLC)

form

powder

mol wt

~1.0 kDa

color

white

solubility

methanol: 2 mg/mL ((further dilute to 10% (v/v) methanol)), DMSO: soluble, ethanol: soluble

storage temp.

−20°C

SMILES string

CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(C)\C=C\[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](C)NC(=O)C(=C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]2C)C(O)=O)C(O)=O

InChI

1S/C52H72N10O13/c1-28(25-29(2)41(75-8)27-34-13-10-9-11-14-34)16-21-37-30(3)44(65)59-39(50(71)72)22-23-42(64)62(7)33(6)47(68)56-32(5)46(67)60-40(26-35-17-19-36(63)20-18-35)49(70)61-43(51(73)74)31(4)45(66)58-38(48(69)57-37)15-12-24-55-52(53)54/h9-11,13-14,16-21,25,29-32,37-41,43,63H,6,12,15,22-24,26-27H2,1-5,7-8H3,(H,56,68)(H,57,69)(H,58,66)(H,59,65)(H,60,67)(H,61,70)(H,71,72)(H,73,74)(H4,53,54,55)/b21-16+,28-25+/t29-,30-,31+,32+,37-,38-,39+,40-,41-,43+/m0/s1

InChI key

OWHASZQTEFAUJC-HVUCWAFBSA-N

General description

Microcystin is a potent cyanotoxin produced by the bloom of Microcystis aeruginosa. It is harmful to aquatic animals. It is a heptapeptide and exists as multiple variant forms. pCO2 and nitrogen levels modulate the toxic variants levels. It elicits damage to the liver and other organs.

Application

Microcystin YR from Microcystis aeruginosa has been used to assess cytotoxicity in neutrophils using DNA fragmentation and cell viability assays and as a reference standard in the quantification of microcystin from water samples.

Biochem/physiol Actions

Microcystin YR inhibits protein phosphatase type 2A and protein phosphatase type 1.
Microcystin YR inhibits protein phosphatase type 2A and protein phosphatase type 1. Toxicity to undifferentiated cells was seen by inhibition of neutral red uptake, >80% at 100 μM, after 48 h.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBS2570V
SLBR1121V
SLBK9229V
SLBH8446V
SLBG7589V

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BIO-CONTROL OF MICROCYSTIS AERUGINOSA BLOOM USING VARIOUS AQUATIC ORGANISMS BY DUAL STABLE ISOTOPE (13 C AND 15 N) TRACERS
Kim MS, et al.
APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH, 16(2), 931-953 (2018)
Analysis of chemokines and reactive oxygen species formation by rat and human neutrophils induced by microcystin-LA,-YR and-LR
Kujbida P, et al.
Toxicon, 51(7), 1274-1280 (2008)
Meric Albay et al.
Environmental toxicology, 20(3), 277-284 (2005-05-14)
The concentration of microcystin (MC) in the Kucukcekmece Lagoon, Istanbul, Turkey, and the physicochemical and biological parameters of water quality were investigated from October 2000 to June 2003. Water samples were collected from surface waters at three sites. Most bloom
Aleksandra Milutinović et al.
Toxicon : official journal of the International Society on Toxinology, 42(3), 281-288 (2003-10-16)
Acute intoxication with MC-LR induces cytoskeletal alterations, apoptosis and necrosis of hepatocytes resulting in intrahepatic hemorrhage. Preliminary results have shown that chronic treatment of rats with intraperitoneal injections of sublethal doses of microcystins MC-LR and MC-YR could induce not only
Xiaofeng Wang et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 37(7), 1181-1207 (2004-08-27)
Three heptapeptide toxins, microcystin-RR, microcystin-RY and microcystin-LR, which can cause health problems in animals and humans were monitored in Bang Phra Reservoir, Thailand using reversed-phase high performance liquid chromatography. The concentrations of the three toxins in the reservoir varied greatly
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