M4145
米诺地尔
≥99% (TLC), powder, potassium channel activator
别名:
6-（1-哌啶基）-2,4-嘧啶二胺 3-氧化物, 6-（1-哌啶基）嘧啶-2,4-二胺 3-氧化物
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关于此项目
经验公式（希尔记法）:
C9H15N5O
化学文摘社编号:
分子量:
209.25
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
米诺地尔, ≥99% (TLC)
质量水平
方案
≥99% (TLC)
mp
272-274 °C (dec.) (lit.)
创始人
Johnson & Johnson
SMILES字符串
NC1=CC(=NC(=N)N1O)N2CCCCC2
InChI
1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChI key
ZIMGGGWCDYVHOY-UHFFFAOYSA-N
基因信息
human ... KCNJ1(3758)
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相关类别
应用
米诺地尔作为测试药物：
- 应用于真皮乳头球体模型中，旨在研究头发再生效果
- 口服给大鼠，识别药物诱导血管损失的生物标志物
- 口服灌胃非人灵长类动物模型，研究其对倾斜反应的效果
生化/生理作用
激活 ATP 激活的 K+ 通道；血管扩张剂；减缓或停止脱发，促进头发再生。
米诺地尔最初用于治疗高血压，也会诱发多毛症。它被视为是治疗雄激素性脱发的有效药物。
特点和优势
该化合物由 Johnson & Johnson 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
C Löffler-Walz et al.
British journal of pharmacology, 123(7), 1395-1402 (1998-05-14)
1. The binding of [3H]-P1075, a potent opener of adenosine-5'-triphosphate-(ATP)-sensitive K+ channels, was studied in a crude heart membrane preparation of the rat, at 37 degrees C. 2. Binding required MgATP. In the presence of an ATP-regenerating system, MgATP supported
Stefan Sarkovich et al.
Journal of experimental orthopaedics, 10(1), 84-84 (2023-08-22)
Synovial fibrosis (SFb) formation and turnover attributable to knee osteoarthritis (KOA) can impart painful stiffness and persist following arthroplasty. To supplement joint conditioning aimed at maximizing peri-operative function, we evaluated the antifibrotic effect of Minoxidil (MXD) on formation of pyridinoline
A non-human primate model for investigating drug-induced risk of orthostatic hypotension and sympathetic dysfunction: Preclinical correlate to a clinical test
Bhatt S, et al.
Journal of Pharmacological and Toxicological Methods, 73(2), 49-55 (2015)
Ilaria Aurigemma et al.
Biochemical and biophysical research communications, 720, 150104-150104 (2024-05-16)
The T-BOX transcription factor TBX1 is essential for the development of the pharyngeal apparatus and it is haploinsufficient in DiGeorge syndrome (DGS), a developmental anomaly associated with congenital heart disease and other abnormalities. The murine model recapitulates the heart phenotype
J I Kourie
The Journal of membrane biology, 164(1), 47-58 (1998-06-24)
The lipid bilayer technique was used to examine the effects of the ATP-sensitive K+ channel inhibitor (glibenclamide) and openers (diazoxide, minoxidil and cromakalim) and Cl- channel activators (GABA and diazepam) on two types of chloride channels in the sarcoplasmic reticulum
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