M4159
亚甲蓝 水合物
suitable for nucleic acid staining, BioReagent
别名:
3,7-双(二甲基氨基)吩噻嗪-5-鎓氯化物, 亚甲蓝, 亚甲蓝一水合物, 核酸染色试剂
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关于此项目
经验公式(希尔记法):
C16H18ClN3S · xH2O
化学文摘社编号:
分子量:
319.85 (anhydrous basis)
Beilstein:
3599847
EC 号:
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.52
等级
Molecular Biology
质量水平
产品线
BioReagent
表单
powder
技术
nucleic acid detection: suitable
溶解性
water: 1 mg/mL (dark blue)
适用性
suitable for nucleic acid staining
储存温度
room temp
SMILES字符串
O.[Cl-].CN(C)c1ccc2N=C3C=C\C(C=C3Sc2c1)=[N+](/C)C
InChI
1S/C16H18N3S.ClH.H2O/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;;/h5-10H,1-4H3;1H;1H2/q+1;;/p-1
InChI key
WQVSELLRAGBDLX-UHFFFAOYSA-M
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一般描述
亚甲蓝是一种杂环芳香化学品,呈深绿色固体粉末状,在水溶液中会变为蓝色。它在许多不同的组织学过程以及分子生物学实验室中被用作染色剂。
应用
亚甲基蓝水合物适合用作琼脂糖和聚丙烯酰胺凝胶电泳(PAGE)的核酸染液。通过使用克隆形成试验,被用于对4T1肿瘤细胞进行染色以研究肿瘤细胞的转移。亚甲基蓝水合物晶体通过被包封在脱铁蛋白纳米笼中,可用于抗肿瘤细胞的光动力学疗法。
特点和优势
- 比溴化乙锭染色的危害更小
- 可在可见光下观察
- 快速且易于使用。
Resolution of multiple ribonucleic acid species by polyacrylamide gel electrophoresis.
A C Peacock et al.
Biochemistry, 6(6), 1818-1827 (1967-06-01)
Ariane Felgenträger et al.
BioMed research international, 2013, 482167-482167 (2013-03-20)
Photodynamic inactivation of bacteria (PIB) by efficient singlet oxygen photosensitizers might be a beneficial alternative to antibiotics in the struggle against multiresistant bacteria. Phenothiazinium dyes belong to the most prominent classes of such sensitizers due to their intense absorption in
Angela L Davis et al.
International journal of molecular sciences, 14(2), 4185-4202 (2013-02-23)
Repurposing approved and abandoned non-oncological drugs is an alternative developmental strategy for the identification of anticancer therapeutics that has recently attracted considerable attention. Due to the essential role of the cellular heat shock response in cytoprotection through the maintenance of
Young-Sharp, D. and Kumar, R.
Technique, 1, 183-183 (1989)
Fei Yan et al.
Photochemistry and photobiology, 86(3), 662-666 (2010-02-06)
This study reports that photosensitizers encapsulated in supramolecular protein cages can be internalized by tumor cells and can deliver singlet oxygen intracellularly for photodynamic therapy (PDT). As an alternative to other polymeric and/or inorganic nanocarriers and nanoconjugates, which may also
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