M4531
甲氯芬那酸 钠盐
别名:
2-[(2,6-二氯-3-甲基苯基)氨基]苯甲酸 钠盐
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线性分子式:
C14H10Cl2NO2Na
化学文摘社编号:
分子量:
318.13
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
228-983-3
MDL number:
InChI key
CHGIZYUDGOIAFY-UHFFFAOYSA-N
InChI
1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;
SMILES string
[Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
biological source
synthetic (organic)
assay
≥93% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to faintly brownish-yellow
water: 50 mg/mL, clear, colorless to faintly yellow
water: 50 mg/mL, clear, colorless to very faintly brown
Quality Level
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相关类别
Application
甲氯芬那酸钠盐已被用于：
- 抑制热诱导的白蛋白变性
- 作为药物制剂，制备用于电生理学研究的灌注液
- 阻止间隙连接
Biochem/physiol Actions
环加氧酶（IC50 = 0.6 μM）和5-脂氧合酶（IC50 = 46.3 μM）抑制剂。
甲氯芬那酸（MFA）是一种非甾体类抗炎药、镇痛药和解热药。它能够抑制前列腺素的生物合成途径，并且被用于治疗术后以及创伤性炎症和肿胀。MFA在打开电压门控性钾通道Q亚家族成员2/成员3（KCNQ2/Q3）方面发挥作用。
General description
甲氯芬那酸由两个垂直扭曲的芳基部分组成，它包括N-2,6-二氯-3-甲基苯基和N-2-苯甲酸基团。由于该化合物的水溶性低，因此能够以钠盐的形式出售。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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