M4603
乙酰基-[Nle4，Asp5，D-2-Nal7，Lys10]-环-α-黑素细胞刺激素酰胺片段4-10
≥95% (HPLC), Melanocortin-4 receptor antagonist
别名:
SHU9119
产品名称
乙酰基-[Nle4，Asp5，D-2-Nal7，Lys10]-环-α-黑素细胞刺激素酰胺片段4-10, ≥95% (HPLC)
assay
≥95% (HPLC)
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... POMC(5443)
相关类别
Biochem/physiol Actions
筛选环状内酰胺黑皮质素激动剂MTII的类似物导致了拟南芥SHU9119的鉴定。该化合物与刺鼠肽具有相同的药理特性，因为它是黑皮质素-4受体的有效拮抗剂和黑皮质素-3受体的较弱拮抗剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
V J Hruby et al.
Journal of medicinal chemistry, 38(18), 3454-3461 (1995-09-01)
The cloning of the melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) receptors (MC1-R and MC2-R, respectively) recently has led to the identification of three additional melanocortin receptors, MC3-R, MC4-R, and MC5-R. The MC2 receptor primarily recognizes only ACTH peptides, but
Anna Fosch et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and the underlying mechanisms have remained largely
W Fan et al.
Nature, 385(6612), 165-168 (1997-01-09)
Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone
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