M4659
米力农
≥97% (TLC), powder, phosphodiesterase type III inhibitor
别名:
1,6-二氢-2-甲基-6-氧-（3,4′-联吡啶）-5-甲腈
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关于此项目
经验公式（希尔记法）:
C12H9N3O
化学文摘社编号:
分子量:
211.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
278-903-6
MDL number:
产品名称
米力农, ≥97% (TLC), powder
Quality Level
assay
≥97% (TLC)
form
powder
color
off-white
solubility
DMSO: >10 mg/mL, H2O: insoluble
originator
Sanofi Aventis
storage temp.
2-8°C
SMILES string
CC1=C(C=C(C#N)C(=O)N1)c2ccncc2
InChI
1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
InChI key
PZRHRDRVRGEVNW-UHFFFAOYSA-N
Gene Information
human ... PDE3A(5139), PDE3B(5140), PDE4B(5142), PDE5A(8654), PTPRA(5786)
rat ... Pde3a(50678)
Biochem/physiol Actions
磷酸二酯酶 Ⅲ 型抑制剂；cAMP 特异性、cGMP 抑制性；强心、正性肌力血管扩张剂。
Features and Benefits
该化合物是环核苷酸研究推荐产品。点击此处 ，查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
该化合物是由 Sanofi Aventis开发。浏览其他由制药公司开发的化合物以及批准药物/候选药物清单， 请单击此处。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Dirk Bassler et al.
The Cochrane database of systematic reviews, (11)(11), CD007802-CD007802 (2010-11-12)
Persistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome characterized by suboptimal oxygenation as a result of sustained elevation in pulmonary vascular resistance after birth. Currently, the therapeutic mainstay for PPHN is optimal lung inflation and selective vasodilatation
Baozeng Xu et al.
Developmental biology, 385(2), 242-252 (2013-11-20)
The oocyte becomes competent for embryonic development by involving mutual communication with cumulus cells (CCs) during folliculogenesis. How this communication takes place under physiological conditions is not fully understood. Current study examined oocyte-CCs communication in the XY sex-revered female mouse.
R Krams et al.
American heart journal, 121(6 Pt 2), 1951-1955 (1991-06-01)
Bipyridine derivatives have recently been introduced as a new class of inodilator drugs in the intravenous therapy of heart failure. A member of this class is milrinone, which improves the inotropic state and reduces ventricular afterload, leading to improved hemodynamics.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M4659-10MG | 04061832898933 |
| M4659-50MG | 04061832898940 |