M4667
3,5-二羟基-3-甲基戊酸内酯
~97% (titration)
别名:
(±)-3-羟基-3-甲基 δ-戊内酯, (±)-β-羟基-β-甲基-δ-戊内酯, DL-甲羟戊酸内酯
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关于此项目
经验公式（希尔记法）:
C6H10O3
化学文摘社编号:
分子量:
130.14
UNSPSC Code:
12352108
NACRES:
NA.25
PubChem Substance ID:
EC Number:
211-615-0
Beilstein/REAXYS Number:
80960
MDL number:
Assay:
~97% (titration)
assay
~97% (titration)
Quality Level
storage temp.
−20°C
SMILES string
CC1(O)CCOC(=O)C1
InChI
1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3
InChI key
JYVXNLLUYHCIIH-UHFFFAOYSA-N
General description
甲羟戊酸内酯碱性水解可产生甲羟戊酸。甲羟戊酸是法呢基焦磷酸和香叶基香叶基焦磷酸的前体。这些焦磷酸盐是蛋白质异戊二烯化所必需的。
Application
(±)-甲羟戊酸内酯用于：
- 研究他汀类药物对Ras和Rho GTP酶异戊二烯化的影响
- 分析单核细胞增多性李斯特菌中类异戊二烯的生物合成途径
- 研究他汀类药物对HUVEC（HGF诱导的人脐静脉内皮细胞）增殖和迁移的影响
Other Notes
也可能是液体！
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
Analysis of the isoprenoid biosynthesis pathways in Listeria monocytogenes reveals a role for the alternative 2-C-methyl-D-erythritol 4-phosphate pathway in murine infection.
Begley M
Infection and Immunity, 76, 5392-5401 (2008)
The effects of different types of statins on proliferation and migration of HGF-induced Human Umbilical Vein Endothelial Cells (HUVECs).
Burgazli KM
European Review for Medical and Pharmacological Sciences, 17, 2874-2883 (2013)
Coenzyme Q 10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway.
Zahiri HS
Metabolic engineering, 8, 406-416 (2006)
Tomoyuki Nishimoto et al.
Toxicology and applied pharmacology, 223(1), 39-45 (2007-06-30)
High-dose statin treatment has been recommended as a primary strategy for aggressive reduction of LDL cholesterol levels and protection against coronary artery disease. The effectiveness of high-dose statins may be limited by their potential for myotoxic side effects. There is
Mareike Bongers et al.
eLife, 9 (2020-03-13)
Volatile isoprenoids produced by plants are emitted in vast quantities into the atmosphere, with substantial effects on global carbon cycling. Yet, the molecular mechanisms regulating the balance between volatile and non-volatile isoprenoid production remain unknown. Isoprenoids are synthesised via sequential
商品
Cholesterol biosynthesis starts in the hepatic endoplasmic reticulum with acetyl-CoA, yielding 3-hydroxy-3-methylglutaryl-CoA via HMG-CoA synthase.
胆固醇的生物合成通常发生在肝细胞的内质网中，并以乙酰辅酶A开始，乙酰辅酶A主要来源于线粒体中的氧化反应。乙酰辅酶A和乙酰乙酰辅酶A由HMG-辅酶A合成酶转化为3-羟基-3-甲基戊二酰辅酶A（HMG-辅酶A）。
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M4667-1G | 04061834059141 |
| M4667-10G | 04061832401911 |
| M4667-5G | 04061832401928 |
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