M4910
1-甲基组胺 二盐酸盐
≥98% (TLC), powder
别名:
1-甲基-4-（β-氨基乙基）咪唑 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C6H11N3 · 2HCl
化学文摘社编号:
分子量:
198.09
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
1-甲基组胺 二盐酸盐, ≥98% (TLC), powder
SMILES string
Cl[H].Cl[H].Cn1cnc(CCN)c1
InChI
1S/C6H11N3.2ClH/c1-9-4-6(2-3-7)8-5-9;;/h4-5H,2-3,7H2,1H3;2*1H
InChI key
AGXVEALMQHTMSW-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
solubility
water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
Gene Information
human ... HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)
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Application
本品（1-甲基组胺二盐酸）可作为标准品，用于通过液相色谱法检测青光眼患者房水中的组氨酸浓度。也可用作胺氧化酶的活性检测底物。
Biochem/physiol Actions
1-甲基组胺存在于大脑中，是由组胺N-甲基转移酶催化组胺生成的代谢产物。它可作为阿尔茨海默病(AD)、睡眠过度等神经疾病患者脑脊液中组胺能神经系统活性的生物标志物。
通过组胺N-甲基转移酶产生的组胺的主要代谢产物。
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Y Hashimoto et al.
Acta anaesthesiologica Scandinavica, 42(7), 858-863 (1998-08-12)
Histamine is most densely distributed in the hypothalamus and has an important effect on consciousness or wakefulness. It has been little considered whether general anesthetics could exert their effects on hypothalamic histamine metabolism. The present study was conducted to investigate
Yves Dauvilliers et al.
Sleep, 35(10), 1359-1366 (2012-10-02)
To determine the activity of cerebral histaminergic system evaluated by CSF levels of histamine (HA) and tele-methylhistamine (t-MHA), its major metabolite, and their relationships with hypocretin-1 levels in a large population of patients with hypersomnia and neurological conditions. sensitive liquid
Koro Gotoh et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(9), 1131-1133 (2005-05-17)
Glucagon-like peptide-1 (GLP-1), corticotropin-releasing hormone (CRH), and hypothalamic neuronal histamine suppress food intake, a target of leptin action in the brain. This study examined the interactions of GLP-1, CRH, and histamine downstream from the leptin-signaling pathway in regulating feeding behavior.
Mouhammad Motawaj et al.
Journal of Alzheimer's disease : JAD, 22(3), 861-871 (2010-09-23)
Neuropathological studies have reported a strong neurofibrillary degeneration of the tuberomamillary nucleus, the region of origin of histamine neurons, in Alzheimer's disease (AD). Histaminergic neurons enhance cognition and memory, suggesting that their degeneration may contribute to the cognitive decline of
Nadia Pelloux-Léon et al.
Journal of medicinal chemistry, 47(12), 3264-3274 (2004-05-28)
4-(3-Aryloxypropyl)-1H-imidazoles, which possess a meta-positioned substituent in the aryl ring, have been synthesized and tested for activity at histamine H(3) receptors. The compounds having a CN, Me, or Br substituent were found to be antagonists, whereas CF(3), Et, i-Pr, t-Bu
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