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Merck
CN

M4937

Anti-Melanocortin-3 Receptor antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

别名:

Anti-MC3R

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, WB
Citations:
8
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biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 40 kDa

species reactivity

rat, mouse (predicted)

technique(s)

microarray: suitable, western blot: 1:2,000 using rat brain homogenate extract

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Mc3r(17201)
rat ... Mc3r(29310)

General description

Melanocortins are regulatory peptides derived from post-translational processing of the larger pro-opiomelanocortin (POMC) precursor. Melanocortin-3 Receptor (MC3-R) is a 360 amino acid containing transmembrane protein that belongs to G-protein coupled receptor family and is expressed mainly in adult central nervous system at high levels in a restricted number of neurons of the hypothalamus and the limbic system.

Immunogen

A synthetic peptide corresponding to the N-terminal region of rat melanocortin receptor 3 (amino acids 15-33) coupled to keyhole limpet hemocyanin (KLH). This sequence is highly conserved in mouse MC3-R (89% identity).

Application

Anti-Melanocortin-3 Receptor antibody produced in rabbit has been used in western blotting and immunocytochemistry.

Biochem/physiol Actions

Melanocortin-3 (MC3) receptor has a crucial role in facilitating the effects of the melanocortin system on energy homeostasis. The MC3 receptor has been proposed to mediate the actions of MSH, in particular those of α-MSH and γ-MSH peptides. MC3-R is thought to regulate fat stores by a metabolic pathway. MC3-R knockout mice (MC3-R-/-) have increased fat mass, but not high body mass index, are hyperleptinaemic and develop mild hyperinsulinaemia. In contrast to MC3-R, MC4-R primarily controls food intake, suggesting that both MC3 and MC4 receptors may play a complementary role in weight control.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
低风险生物材料
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Mc3 and Mc4 receptors: complementary role in weight control
Raffin S M L, et al.
European Journal of Endocrinology, 144(1), 207-208 (2019)
Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion
Leoni G, et al.
Faseb Journal, 22(12), 4228-4238 (2008)
Paul M Holloway et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(9), 1936-1944 (2015-06-27)
Neutrophil recruitment is a key process in the pathogenesis of stroke, and may provide a valuable therapeutic target. Targeting the melanocortin (MC) receptors has previously shown to inhibit leukocyte recruitment in peripheral inflammation, however, it is not known whether treatments
A S Chen et al.
Nature genetics, 26(1), 97-102 (2000-09-06)
Genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has remained unknown. We evaluated the
Magdalena K Kaneva et al.
British journal of pharmacology, 167(1), 67-79 (2012-04-05)
Melanocortin MC(1) and MC(3 ) receptors, mediate the anti-inflammatory effects of melanocortin peptides. Targeting these receptors could therefore lead to development of novel anti-inflammatory therapeutic agents. We investigated the expression of MC(1) and MC(3) receptors on chondrocytes

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