Anti-Melanocortin-3 Receptor antibody produced in rabbit

Melanocortins are regulatory peptides derived from post-translational processing of the larger pro-opiomelanocortin (POMC) precursor. Melanocortin-3 Receptor (MC3-R) is a 360 amino acid containing transmembrane protein that belongs to G-protein coupled receptor family and is expressed mainly in adult central nervous system at high levels in a restricted number of neurons of the hypothalamus and the limbic system.

A synthetic peptide corresponding to the N-terminal region of rat melanocortin receptor 3 (amino acids 15-33) coupled to keyhole limpet hemocyanin (KLH). This sequence is highly conserved in mouse MC3-R (89% identity).

Anti-Melanocortin-3 Receptor antibody produced in rabbit has been used in western blotting and immunocytochemistry.

Melanocortin-3 (MC3) receptor has a crucial role in facilitating the effects of the melanocortin system on energy homeostasis. The MC3 receptor has been proposed to mediate the actions of MSH, in particular those of α-MSH and γ-MSH peptides. MC3-R is thought to regulate fat stores by a metabolic pathway. MC3-R knockout mice (MC3-R-/-) have increased fat mass, but not high body mass index, are hyperleptinaemic and develop mild hyperinsulinaemia. In contrast to MC3-R, MC4-R primarily controls food intake, suggesting that both MC3 and MC4 receptors may play a complementary role in weight control.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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