产品名称
髓鞘少突胶质细胞糖蛋白肽片段35-55, immunodominant epitope of MOG
Quality Level
assay
≥97% (HPLC)
form
powder
color
white
application(s)
cell analysis
storage temp.
−20°C
Gene Information
mouse ... Mog(17441)
rat ... Mog(24558)
General description
髓鞘少突胶质细胞糖蛋白（MOG）是中枢神经系统的组成部分，存在于少突胶质细胞和髓鞘的表面。它的细胞外结构域被广泛用于创建多发性硬化的自身免疫动物模型。在大鼠中，MOG表达于海马体中。
Application
- 红细胞生成素及其非红细胞生成素衍生物的延迟给药减轻鼠类慢性自身免疫性脑脊髓炎。: 该论文考察了红细胞生成素及其衍生物在自身免疫性脑脊髓炎治疗中的延迟治疗给药（Savino et al., 2006》
- 5-羟色胺再摄取的缺乏影响小鼠EAE中临床自身免疫性疾病的易感性和神经抗原特异性干扰素-γ的生成。: 该研究采用髓鞘少突胶质细胞糖蛋白35-55 片段来诱导小鼠中实验性自身免疫性脑脊髓炎，探索了5-羟色胺再摄取在调节免疫反应和自身免疫性疾病易感性的作用（Hofstetter et al., 2005）。
- 以组蛋白去乙酰化酶抑制剂曲古抑菌素A进行的转录治疗减轻实验性自身免疫性脑脊髓炎。: 该研究证实了组蛋白去乙酰化酶抑制剂曲古抑菌素A在治疗实验性自身免疫性脑脊髓炎方面的有效性。研究人员采用髓鞘少突胶质细胞糖蛋白35-55 片段来诱导大鼠和小鼠疾病模型，提供了有关潜在表观遗传治疗的见解（Camelo et al., 2005）。
Biochem/physiol Actions
诱导啮齿动物的实验性自身免疫性脑脊髓炎模型；单次注射这种肽，可产生复发-缓解型神经系统疾病，表现出大量斑块状脱髓鞘病症；免疫接种MOG（35-55），能抑制MPTP损伤的多巴胺能神经元的自发再生功能。
Other Notes
从0.1％TFA水溶液中冻干
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M4939-1MG | 04061838446763 |
| M4939-.5MG | 04061832821832 |
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