Anti-Myosin Va (LE-16) antibody produced in rabbit

Myosin Va (p190) is a member of the unconventional class of myosins, distinct from both the myosins I and myosin II. It is present in neuronal and non neuronal cells of the brain. Class V myosins are widely expressed actin-based motors. Class V myosins have two motor head domains typical of myosins, and an extended regulatory neck domain with six tandem IQ domains that bind multiple calmodulin light chains. In addition, myosin V contains a unique 400 amino acids globular tail domain that may direct myosin V to its target or determine the cargo to which it binds.

synthetic peptide located near the C-terminus of chicken myosin Va (amino acids 1705-1720 with N-terminally added lysine) conjugated to KLH. This sequence is identical in human, mouse and rat.

Anti-Myosin Va (LE-16) antibody produced in rabbit is used in immunoblotting and immunohistochemistry.

Myosin Va is implicated in the regulation of vesicle trafficking in neurons and melanocytes. It regulates melanosome distribution along microfilaments. It is found in association with the centrosome at all stages of the cell cycle. In the interphase stage, myosin Va is found in pericentriolar material. During cell division, it is found in the cytoplasm and concentrates in a trail between migrating centrioles and in the mitotic spindle poles and spindle fibers.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

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