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Merck
CN

M5255

霉酚酸

from Penicillium brevicompactum, ≥98% (HPLC), powder, IMP dehydrogenase inhibitor

别名:

6-（1,3-二氢-7-羟基-5-甲氧基-4-甲基-1-氧代异苯并呋喃-6-基）-4-甲基-4-己酸, 6-（4-羟基-6-甲氧基-7-甲基-3-氧代-5-酞酰）-4-甲基-4-己烯酸, NSC 129185

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关于此项目

经验公式（希尔记法）:
C17H20O6
化学文摘社编号:
24280-93-1
分子量:
320.34
NACRES:
NA.77
PubChem Substance ID:
24896987
UNSPSC Code:
12352106
EC Number:
246-119-3
MDL number:
MFCD00036814
Beilstein/REAXYS Number:
1295848

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产品名称

霉酚酸, ≥98%

InChI key

HPNSFSBZBAHARI-RUDMXATFSA-N

InChI

1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+

SMILES string

COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O

biological source

Penicillium brevicompactum

assay

≥98%

color

white to yellow-white

mp

<143.0 °C

solubility

methanol: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

mode of action

enzyme | inhibits

originator

Novartis

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... IMPDH1(3614), IMPDH2(3615)

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相关类别

Application

霉酚酸 (MPA) 由 青霉 (Penicillum brevi-compactum) 产生 ，是一种选择性的肌苷一磷酸脱氢酶抑制剂，从而抑制 T、B 淋巴细胞的 DNA 合成。在人淋巴和单核细胞系中，它还被证明可作为免疫抑制剂，以及单核细胞分化和凋亡的诱导剂。作为选择剂，MPA 用于表达大肠杆菌黄嘌呤-鸟嘌呤磷酸核糖转移酶基因的转染动物细胞，推荐使用 25μg/mL。

Biochem/physiol Actions

作用方式：本品通过抑制细胞因子诱导的一氧化氮生成，抑制嘌呤核苷酸的早期生物合成，并作为 IMP 脱氢酶的特异性抑制剂发挥作用。

Features and Benefits

该化合物由 Novartis 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表，请 点击这里 。

Preparation Note

麦考酚酸可溶于 50 mg/mL 甲醇，产生无色至淡黄色溶液，以及氯仿、二氯甲烷、乙醇和 1 N 氢氧化钠溶液。复溶后，建议通过 0.22 μm 过滤器灭菌m 孔径过滤器，分装，-20°C 冷冻。

Disclaimer

供应后，本品应在 2-8°C 干燥条件下储存，适当储存时可保持稳定 5 年。

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral

target_organs

Immune system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000445541
0000445541
0000359869
0000359869
0000246560

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Current genetics, 66(4), 813-822 (2020-04-02)
Slowing down aging-associated accumulation of molecular damage or its prevention represents a promising therapeutic paradigm to combat aging-related disease and death. While several chemical compounds extend lifespan in model organisms, their mechanism of action is often unknown, reducing their therapeutic
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This review seeks to summarize the available data about Bayesian estimation of area under the plasma concentration-time curve (AUC) and dosage prediction for mycophenolic acid (MPA) and evaluate whether sufficient evidence is available for routine use of Bayesian dosage prediction
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Mycophenolate mofetil (MMF) is widely used for maintenance immunosuppressive therapy in pediatric renal and heart transplant recipients. Children undergo developmental changes (ontogeny) of drug disposition, which may affect drug metabolism of the active compound mycophenolic acid (MPA). Therefore, a detailed
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Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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Data Sheet - M5255

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