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M5449

MKT-077

Name: MKT-077
Brand: SIGMA

≥98% (HPLC), powder

别名:

1-乙基-2- [[3-乙基-5-（3-甲基-2 (3H)-苯并噻唑亚甲基）-4-氧代-2-噻唑亚基] 甲基]-氯化吡啶, FJ-776

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关于此项目

线性分子式:

C₂₁H₂₂N₃OS₂Cl

化学文摘社编号:

147366-41-4

分子量:

432.00

NACRES:

NA.77

PubChem Substance ID:

329818014

UNSPSC Code:

12352200

MDL number:

MFCD27665468

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

orange to red

solubility

H₂O: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C1=C(S/2)C=CC=C1)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](CC)C=CC=C4)=O.[Cl-]

InChI

1S/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21;/h6-14H,4-5H2,1-3H3;1H/q+1;/p-1/b21-19+;

InChI key

VSKYOTRJSLYFHX-UXJRWBAGSA-M

Biochem/physiol Actions

MKT-077 是线粒体 hsp70 家族成员致死蛋白 (mot-2) n 的抑制剂

MKT-077 是线粒体 hsp70 家族成员致死蛋白 (mot-2) n 的抑制剂；它导致癌细胞选择性死亡。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.

Tuoen Liu et al.

PloS one, 12(2), e0170470-e0170470 (2017-02-09)

Myelodysplastic syndromes (MDS) are the most common adult myeloid blood cancers in the US. Patients have increased apoptosis in their bone marrow cells leading to low peripheral blood counts. The full complement of gene mutations that contribute to increased apoptosis

The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite.

Jemma Day et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 14611-14624 (2019-11-07)

Plasmodium falciparum is the most lethal of human-infective malaria parasites. A hallmark of P. falciparum malaria is extensive remodeling of host erythrocytes by the parasite, which facilitates the development of virulence properties such as host cell adhesion to the endothelial

Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC.

Victoria J Gennaro et al.

BMC cancer, 19(1), 258-258 (2019-03-25)

The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical determinant of this cell fate

75-kDa glucose-regulated protein (GRP75) is a novel molecular signature for heat stress response in avian species.

Ahmed Edan Dhamad et al.

American journal of physiology. Cell physiology, 318(2), C289-C303 (2019-12-05)

Glucose-regulated protein 75 (GRP75) was first characterized in mammals as a heat shock protein-70 (HSP70) family stress chaperone based on its sequence homology. Extensive studies in mammals showed that GRP75 is induced by various stressors such as glucose deprivation, oxidative

Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells.

Sujit Pujhari et al.

Emerging microbes & infections, 8(1), 8-16 (2019-03-15)

Zika virus (ZIKV) is a historically neglected mosquito-borne flavivirus that has caused recent epidemics in the western hemisphere. ZIKV has been associated with severe symptoms including infant microcephaly and Guillain-Barré syndrome, stimulating interest in understanding factors governing ZIKV infection. Heat

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全球贸易项目编号

货号	GTIN
M5449-25MG	04061832722900
M5449-5MG	04061832722917

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