M5449
MKT-077
≥98% (HPLC), powder
别名:
1-乙基-2- [[3-乙基-5-（3-甲基-2 (3H)-苯并噻唑亚甲基）-4-氧代-2-噻唑亚基] 甲基]-氯化吡啶, FJ-776
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关于此项目
线性分子式:
C21H22N3OS2Cl
化学文摘社编号:
分子量:
432.00
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
MKT-077, ≥98% (HPLC), powder
InChI key
VSKYOTRJSLYFHX-UXJRWBAGSA-M
SMILES string
CN(C1=C(S/2)C=CC=C1)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](CC)C=CC=C4)=O.[Cl-]
InChI
1S/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21;/h6-14H,4-5H2,1-3H3;1H/q+1;/p-1/b21-19+;
assay
≥98% (HPLC)
form
powder
color
orange to red
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
MKT-077 是线粒体 hsp70 家族成员致死蛋白 (mot-2) n 的抑制剂
MKT-077 是线粒体 hsp70 家族成员致死蛋白 (mot-2) n 的抑制剂；它导致癌细胞选择性死亡。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Myelodysplastic syndromes (MDS) are the most common adult myeloid blood cancers in the US. Patients have increased apoptosis in their bone marrow cells leading to low peripheral blood counts. The full complement of gene mutations that contribute to increased apoptosis
Victoria J Gennaro et al.
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The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical determinant of this cell fate
Sunil Joseph et al.
Biology open, 6(4), 481-488 (2017-03-16)
Earlier studies suggested that
Ahmed Edan Dhamad et al.
American journal of physiology. Cell physiology, 318(2), C289-C303 (2019-12-05)
Glucose-regulated protein 75 (GRP75) was first characterized in mammals as a heat shock protein-70 (HSP70) family stress chaperone based on its sequence homology. Extensive studies in mammals showed that GRP75 is induced by various stressors such as glucose deprivation, oxidative
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