M5571
米替福新
≥98% (perchloric acid titration)
别名:
十六烷基胆碱磷酸（抗肿瘤药）, 肝细胞癌, 胆碱十六烷基磷酸酯
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C21H46NO4P
化学文摘社编号:
分子量:
407.57
MDL编号:
UNSPSC代码:
51191904
PubChem化学物质编号:
NACRES:
NA.85
生物来源
synthetic (organic)
质量水平
描述
zwitterionic
方案
≥98% (perchloric acid titration)
表单
powder
溶解性
H2O: 10 mg/mL, clear, colorless
官能团
phospholipid
脂质类型
phospholipids
储存温度
room temp
SMILES字符串
[O-]P(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCC)=O
InChI
1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
InChI key
PQLXHQMOHUQAKB-UHFFFAOYSA-N
正在寻找类似产品? 访问 产品对比指南
应用
- 作为一类新型抗利什曼原虫药物的多功能化吲哚吡咯杂化物的简易一锅法合成。: 这项研究强调了在患者对已知药物（如用作阳性对照参考品的米替福新）的耐药性日益增强的情况下，创新治疗的必要性，这可能为抗利什曼原虫药物的开发开辟新的方向（Ciccone et al., 2024）。
生化/生理作用
蛋白激酶C和磷脂酰胆碱合成抑制剂。用于内脏和皮肤利什曼病的治疗。对阴道毛滴虫甲硝唑耐药株和敏感株有效
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Thomas P C Dorlo et al.
Antimicrobial agents and chemotherapy, 52(8), 2855-2860 (2008-06-04)
The pharmacokinetics of miltefosine in leishmaniasis patients are, to a great extent, unknown. We examined and characterized the pharmacokinetics of miltefosine in a group of patients with Old World (Leishmania major) cutaneous leishmaniasis. Miltefosine plasma concentrations were determined in samples
M Rakotomanga et al.
Antimicrobial agents and chemotherapy, 51(4), 1425-1430 (2007-01-24)
Miltefosine (hexadecylphosphocholine [HePC]) is the first orally active antileishmanial drug. Transient HePC treatment of Leishmania donovani promastigotes at 10 microM significantly reduced the phosphatidylcholine content and enhanced the phosphatidylethanolamine (PE) content in parasite membranes, suggesting a partial inactivation of PE-N-methyltransferase.
Thomas P C Dorlo et al.
The Journal of antimicrobial chemotherapy, 67(11), 2576-2597 (2012-07-27)
Miltefosine is an alkylphosphocholine drug with demonstrated activity against various parasite species and cancer cells as well as some pathogenic bacteria and fungi. For 10 years it has been licensed in India for the treatment of visceral leishmaniasis (VL), a
Suresh K Tipparaju et al.
Journal of medicinal chemistry, 51(23), 7344-7347 (2008-11-08)
The first synthesis and biological evaluation of antibiotic 31 (A-33853) and its analogues are reported. Initial screening for inhibition of L. donovani, T. b. rhodesiense, T. cruzi, and P. falciparum cultures followed by determination of IC(50) in L. donovani and
Nathan P Wiederhold et al.
Antimicrobial agents and chemotherapy, 57(2), 745-750 (2012-11-21)
Miltefosine is an alkyl phosphocholine with good oral bioavailability and in vitro activity against Cryptococcus species that has gained interest as an additional agent for cryptococcal infections. Our objective was to further evaluate the in vivo efficacy of miltefosine in
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持