M5644
(±)-甲氧基维拉帕米 盐酸盐
≥98%
别名:
戈洛帕米, (±)-α-[3-[(2-(3,4-二甲氧基苯基)乙基)甲氨基]丙基]-3,4,5-三甲氧基-α-(1-甲基乙基)苯乙腈 盐酸盐, D 600
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关于此项目
经验公式（希尔记法）:
C28H40N2O5 · HCl
化学文摘社编号:
分子量:
521.09
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C28H40N2O5.ClH/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5;/h10-11,16-18,20H,9,12-15H2,1-8H3;1H
SMILES string
Cl[H].COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC
InChI key
OKCRIUNHEQSXFD-UHFFFAOYSA-N
assay
≥98%
Quality Level
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General description
甲氧维拉帕米是一种钙调素拮抗剂。通过调节钙信号控制鞭毛糖蛋白再分布。甲氧维拉帕米影响细胞内钙水平的影响，并影响精子获能功能。
Application
(±)-甲氧基维拉帕米盐酸盐已被用于：
- 在 曼氏血吸虫 寄生虫
- 中作为钙通道拮抗剂在培养的巨噬细胞中作为钙条目阻滞剂
- 在 L 型电压门控 Ca 2 + 通道抑制
Biochem/physiol Actions
阻断 L 型 Ca2+ 通道
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Inhibition of cholesteryl ester deposition in macrophages by calcium entry blockers: an effect dissociable from calcium entry blockade
Daugherty A, et al.
British Journal of Pharmacology, 91(1), 113-118 (1987)
Calcium influx regulates antibody-induced glycoprotein movements within the Chlamydomonas flagellar membrane
Bloodgood RA and Salomonsky NL
Journal of Cell Science, 96(1), 27-33 (1990)
Hidetada Matsuoka et al.
American journal of physiology. Cell physiology, 296(4), C889-C899 (2009-01-30)
It has been suggested that store-operated Ca(2+) entry (SOC) facilitates catecholamine secretion and synthesis in bovine adrenal medullary (AM) cells. However, there has been no experimental result clearly showing that cation channel activity is enhanced by store Ca(2+) depletion. Thus
Beatrice Pöschel et al.
Neuropharmacology, 52(1), 46-54 (2006-08-11)
Hippocampal long-term depression (LTD) comprises a persistent reduction of synaptic strength that is typically induced by low frequency stimulation (LFS). Although LTD has been described for the dentate gyrus in vitro, this phenomenon in the dentate gyrus of the intact
Wayne M Mullett et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 801(2), 297-306 (2004-01-31)
A new molecularly imprinted polymer (MIP) material was synthesized selective for verapamil and utilized for on-line metabolic screening of this common calcium antagonist in biological samples. Since some metabolites of verapamil have also shown pharmacological properties, a selective and sensitive
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