M5644
(±)-甲氧基维拉帕米 盐酸盐
≥98%
别名:
戈洛帕米, (±)-α-[3-[(2-(3,4-二甲氧基苯基)乙基)甲氨基]丙基]-3,4,5-三甲氧基-α-(1-甲基乙基)苯乙腈 盐酸盐, D 600
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关于此项目
经验公式（希尔记法）:
C28H40N2O5 · HCl
化学文摘社编号:
分子量:
521.09
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C28H40N2O5.ClH/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5;/h10-11,16-18,20H,9,12-15H2,1-8H3;1H
SMILES string
Cl[H].COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2cc(OC)c(OC)c(OC)c2)cc1OC
InChI key
OKCRIUNHEQSXFD-UHFFFAOYSA-N
assay
≥98%
Quality Level
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General description
甲氧维拉帕米是一种钙调素拮抗剂。通过调节钙信号控制鞭毛糖蛋白再分布。甲氧维拉帕米影响细胞内钙水平的影响，并影响精子获能功能。
Application
(±)-甲氧基维拉帕米盐酸盐已被用于：
- 在 曼氏血吸虫 寄生虫
- 中作为钙通道拮抗剂在培养的巨噬细胞中作为钙条目阻滞剂
- 在 L 型电压门控 Ca 2 + 通道抑制
Biochem/physiol Actions
阻断 L 型 Ca2+ 通道
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
D N Serban et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 108(2), 445-451 (2005-02-04)
Membrane potential (MP) is essential in smooth muscle (SM) contractile activity, mainly by its effect upon L-type Ca2+ channels. We simultaneously recorded SM isometric tension and MP in de-endothelised rat aorta rings and examined their submaximal activation by K+, norepinephrine
Anamika Awasthi et al.
Bioorganic & medicinal chemistry letters, 15(24), 5412-5415 (2005-10-11)
Ab initio Hartree-Fock calculations have been performed at the 6-31G level to study the pharmacophoric features of verapamil. Both the unprotonated and the protonated forms of verapamil have been studied. The study predicts that the drug enters the body in
Iliyana D Stefanova et al.
Molecular nutrition & food research, 51(4), 468-472 (2007-03-16)
Melanoidins obtained from L-arginine and D-glucose (MW > 3500 Da) were tested for their ability to influence the contractility of gastric smooth muscles. A study within the range 0.1-10 mg/mL revealed that at low concentrations, the melanoidins provoked concentration-dependent contraction
Xian Wang et al.
Biosensors & bioelectronics, 166, 112399-112399 (2020-07-22)
Heart failure fundamentally results from loss of cardio myocyte contractility. Developing new methods that quantify the contractile stress of the human cardiomyocyte would facilitate the study of the molecular mechanism of heart failure and advance therapy development, to improve the
Ho Jae Han et al.
Life sciences, 76(25), 2903-2919 (2005-04-12)
Embryonic stem (ES) cells are provided as a powerful tool for developmental biology and have been shown to respond to insulin. However, little is known about the effect of insulin on [Ca2+]i regulation in the ES cells, although many cellular
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