M5793
3-吗啉吡啶亚胺 盐酸盐
guanylyl cyclase activator
别名:
3-（4-吗啉基）丁香酮亚胺 盐酸盐, SIN-1 盐酸盐, 林西多明 盐酸盐
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关于此项目
经验公式（希尔记法）:
C6H10N4O2 · HCl
化学文摘社编号:
分子量:
206.63
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Quality level:
产品名称
3-吗啉吡啶亚胺 盐酸盐, (consistent with structure, NMR)
Quality Level
storage temp.
−20°C
SMILES string
Cl[H].[NH-]c1c[n+](no1)N2CCOCC2
InChI
1S/C6H10N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5,7H,1-4H2;1H
InChI key
NCGICGYLBXGBGN-UHFFFAOYSA-N
Application
3-吗啉斯德酮亚胺盐酸盐已用于：
- 作为过氧亚硝酸盐供体标准品，研究过氧亚硝酸盐在拟南芥中的积聚现象
- 研究其对人脑血管周细胞和人胚胎肾细胞硝化应激的影响
- 研究其作为活性氧物质(ROS)对小鼠胚胎成纤维细胞的影响
Biochem/physiol Actions
3-吗啉斯德酮亚胺参与半胱氨酸蛋白酶抑制。
在溶液中自发释放一氧化氮 (NO)，激活鸟苷酸环化酶并引起循环 GMP 增加。本品为血管扩张剂，可抑制血小板聚集。它利用分子氧产生超氧阴离子和一氧化氮，自发形成过氧亚硝基阴离子。
溶解时自发释放一氧化氮 (NO)，激活鸟苷酸环化酶，引起环鸟苷酸增多；血管扩张剂。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。
Kittipot Sirichaiwetchakoon et al.
BioMed research international, 2020, 4183643-4183643 (2020-10-09)
Tea is one of the most popular beverages in the world. Camellia sinensis tea (CST) or green tea is widely regarded as a potent antioxidant. In Thailand, Pluchea indica (L.) Less. tea (PIT) has been commercially available as a health-promoting
P Ascenzi et al.
Current protein & peptide science, 2(2), 137-153 (2002-10-09)
Cysteine proteases represent a broad class of proteolytic enzymes widely distributed among living organisms. Although well known as typical lysosomal enzymes, cysteine proteases are actually recognized as multi-function enzymes, being involved in antigen processing and presentation, in membrane-bound protein cleavage
Keren Zohar et al.
Biomedicines, 9(9) (2021-09-29)
A hallmark of the aging brain is the robust inflammation mediated by microglial activation. Pathophysiology of common neurodegenerative diseases involves oxidative stress and neuroinflammation. Chronic treatment of aging rats by ladostigil, a compound with antioxidant and anti-inflammatory function, prevented microglial
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M5793-100MG | 04061834060369 |
| M5793-25MG | 04061834060376 |