Name: (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₂₀H₂₈N₄O₄

CAS Number:

142880-36-2

分子量:

388.46

UNSPSC代码:

12352200

PubChem化学物质编号:

329818026

NACRES:

NA.77

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质量水平

200

方案

>95% (HPLC)

表单

solid

储存温度

2-8°C

SMILES字符串

CNC([C@@H](NC([C@@H](C(C)C)CC(NC)=O)=O)CC1=CNC2=CC=CC=C21)=O

InChI

1S/C20H28N4O3/c1-12(2)15(10-18(25)21-3)19(26)24-17(20(27)22-4)9-13-11-23-16-8-6-5-7-14(13)16/h5-8,11-12,15,17,23H,9-10H2,1-4H3,(H,21,25)(H,22,27)(H,24,26)/t15-,17+/m1/s1

InChI key

PFBWZAGFLVKAGR-WBVHZDCISA-N

应用

(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide has been used:

To study its effect on the profiling of active aggrecanases and their specific aggrecan degradation fragments.
To study the involvement of autocrine EGF (epidermal growth factor) receptor activation in the regulation of the morphogenetic process, using human umbilical vein endothelial cells.
To study the effect of GM6001 blockade on the expression of angiotensin II, the interstitial collagenases and soluble elastin fragments in explant culture supernatants.

生化/生理作用

GM6001 promotes cardiovascular and hepatocellular function.

Inhibits a wide variety of matrix metalloproteases with K_is in the nanomolar range. Active in a number of animal models of diseases where matrix metalloproteases are thought to be involved.