M5942
MRS 2395
≥98% (HPLC), P2Y12 purinoceptor antagonist, solid
别名:
2,2-二甲基丙酸3-(2-氯-6-甲基氨基嘌呤-9-基)-2-(2,2-二甲基-丙酰氧基甲基)-丙酯
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H30ClN5O4
化学文摘社编号:
分子量:
439.94
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
MRS 2395, ≥98% (HPLC), solid
SMILES string
CNc1nc(Cl)nc2n(CC(COC(=O)C(C)(C)C)COC(=O)C(C)(C)C)cnc12
InChI
1S/C20H30ClN5O4/c1-19(2,3)16(27)29-9-12(10-30-17(28)20(4,5)6)8-26-11-23-13-14(22-7)24-18(21)25-15(13)26/h11-12H,8-10H2,1-7H3,(H,22,24,25)
InChI key
NASABYJQIYJDID-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: >10 mg/mL
H2O: insoluble
Quality Level
相关类别
Biochem/physiol Actions
P2Y12嘌呤受体拮抗剂。
P2Y12嘌呤受体的拮抗剂；在大鼠血小板中抑制ADP诱导的聚集，并在PGE1存在下拮抗大鼠和人血小板中ADP诱导的cAMP抑制，而不会影响转染的星形细胞瘤细胞中P2Y1受体诱导的PLC活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Josiane S Neves et al.
The Journal of allergy and clinical immunology, 125(2), 477-482 (2010-02-18)
Cysteinyl leukotrienes (cysLTs) are recognized to act via receptors (cysLTRs) expressed on cell surface plasma membranes. Agents that block cysLT(1) receptor (cysLT(1)R) are therapeutics for allergic disorders. Eosinophils contain multiple preformed proteins stored within their intracellular granules. Cell-free eosinophil granules
Bin Xu et al.
Journal of medicinal chemistry, 45(26), 5694-5709 (2002-12-13)
Activation by ADP of both P2Y(1) and P2Y(12) receptors in platelets contributes to platelet aggregation, and antagonists at these receptor subtypes have antithrombotic properties. In an earlier publication, we have characterized the SAR as P2Y(1) receptor antagonists of acyclic analogues
M G Zizzo et al.
British journal of pharmacology, 151(1), 73-81 (2007-03-14)
This study analysed the contribution of the purinergic system to enteric neurotransmission in the longitudinal muscle of mouse distal colon. Motor responses to exogenous ATP and to nerve stimulation in vitro were assessed as changes in isometric tension. ATP induced
Annachiara Mitrugno et al.
Platelets, 29(4), 383-394 (2017-05-20)
The release of ADP from platelet dense granules and its binding to platelet P2Y12 receptors is key to amplifying the initial hemostatic response and propagating thrombus formation. P2Y12 has thus emerged as a therapeutic target to safely and effectively prevent
Juan F Guarracino et al.
Neuroscience, 326, 31-44 (2016-04-09)
It is known that adenosine 5'-triphosphate (ATP) is released along with the neurotransmitter acetylcholine (ACh) from motor nerve terminals. At mammalian neuromuscular junctions (NMJs), we have previously demonstrated that ATP is able to decrease ACh secretion by activation of P2Y
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持