Product Name
巨噬细胞集落刺激因子 人, M-CSF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
生物来源
human
质量水平
重组
expressed in E. coli
方案
≥98% (SDS-PAGE and HPLC)
表单
lyophilized powder
效能
0.500-5.000 ng/mL ED50
质量
endotoxin tested
分子量
dimer 37 kDa
包装
pkg of 10 μg
技术
cell culture | mammalian: suitable
杂质
≤1.000 EU/μg
颜色
white
UniProt登记号
储存温度
−20°C
基因信息
human ... CSF1(1435)
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一般描述
Macrophage Colony-Stimulating Factor (M-CSF) is a hematopoietic growth factor, which modulates the proliferation, differentiation and functional activation of monocytes. It is produced by fibroblasts, endothelial cells and bone marrow stromal cells. MCSF stimulates the functions of mature monocytes and macrophages.
应用
Macrophage Colony-Stimulating Factor human has been used for the differentiation of bone marrow-derived macrophages (BMDMs) and human monocyte-derived macrophages (MDMs). It has also been used for cell culture.
生化/生理作用
Macrophage colony-stimulating factor (M-CSF) augments many of the physiological functions of macrophages, and support osteoclast differentiation.
外形
Lyophilized from a sterile filtered buffered solution.
分析说明
The proliferative activity is tested in culture using the cytokine-dependent murine monocytic cell line M-NFS-60 cells.
其他说明
159 amino acids including N-terminal methionine (each monomer).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Yuhao Liu et al.
Theranostics, 9(16), 4648-4662 (2019-08-02)
Rationale: Osteoporosis is a severe bone disorder that is a threat to our aging population. Excessive osteoclast formation and bone resorption lead to changes in trabecular bone volume and architecture, leaving the bones vulnerable to fracture. Therapeutic approaches of inhibiting
Avery's Diseases of the Newborn (2012)
Encyclopedia of Immunology (1998)
MIR144 inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2
Kim JK, et al.
Autophagy, 13(2), 423-441 (2017)
Phenotypic and functional characterization of monoclonal antibodies with specificity for rhesus macaque CD200, CD200R and Mincle
Byrareddy SN, et al.
PLoS ONE, 10(10), e0140689-e0140689 (2015)
商品
Read article on hematopoietic cytokines and hematopoiesis
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